Products Lormetazepam is commercially available in tablet form (Loramet). Both drugs have been approved in many countries since 1981. Noctamide is no longer marketed. Structure and properties Lormetazepam (C16H12Cl2N2O2, Mr = 335.18 g/mol) is an -methylated lorazepam (Temesta). It belongs to the 5-aryl-1,4-benzodiazepines. Effects Lormetazepam (ATC N05CD06) has antianxiety, sedative, sleep-inducing, anticonvulsant, and muscle relaxant … Lormetazepam
Products Flurazepam is commercially available in tablet form (Dalmadorm). It has been approved in many countries since 1972. Structure and properties Flurazepam (C21H23ClFN3O, Mr = 387.9 g/mol) is a 1,4-benzodiazepine. It is present in drugs as flurazepam hydrochloride, a white crystalline powder that is very soluble in water. Effects Flurazepam (ATC N05CD01) has sleep-inducing and … Flurazepam
Products Flunitrazepam is commercially available in the form of film-coated tablets (Rohypnol). It has been approved in many countries since 1975. Structure and properties Flunitrazepam (C16H12FN3O3, Mr = 313.3 g/mol) is a lipophilic, fluorinated and nitrated 1,4-benzodiazepine. It exists as a white to yellowish crystalline powder that is practically insoluble in water. Effects Flunitrazepam (ATC … Flunitrazepam
Products Midazolam is commercially available as film-coated tablets and as a solution for injection (Dormicum, generic). It has been approved in many countries since 1982. Midazolam nasal spray has not yet been registered in many countries and must be prepared in a pharmacy as an extemporaneous formulation or imported. In 2012, a solution for use … Midazolam
Products In many countries, midazolam nasal spray is not yet available and registered as a finished drug product and therefore must be prepared as an extemporaneous formulation in a pharmacy or, at most, imported from abroad. It was approved in the United States in 2019 (Nayzilam). See also under diazepam nasal spray. Structure and properties … Midazolam Nasal Spray
Products Clobazam is commercially available in tablet form (Urbanyl). It has been approved in many countries since 1979. Structure and properties Clobazam (C16H13ClN2O2, Mr = 300.7 g/mol) exists as a white crystalline powder that is sparingly soluble in water. It belongs structurally to the 1,5-benzodiazepines. The other active ingredients are 1,4-benzodiazepines. Effects Clobazam (ATC N05BA09) … Clobazam
Products Diazepam is commercially available in tablet, drop, solution for injection, and enema form (Valium, generic). It has been approved in many countries since 1962. In 2020, a diazepam nasal spray was released in the United States. Diazepam was developed by Leo Sternbach at Hoffmann-La Roche as the second member of the benzodiazepine group. Structure … Diazepam: Drug Effects, Side Effects, Dosage and Uses
Products Valtoco diazepam nasal spray was approved in the United States in 2020. The benzodiazepine diazepam has been available in other dosage forms since the 1960s. Structure and properties Diazepam (C16H13ClN2O, Mr = 284.7 g/mol) is a lipophilic benzodiazepine. It exists as a white crystalline powder that is very sparingly soluble in water. Effects Diazepam … Diazepam Nasal Spray
Products Tetrazepam is commercially available in some countries in tablet form. The drug is not registered in many countries. In April 2013, the European Medicines Agency recommended that the drug be withdrawn from the market throughout Europe because very rare severe skin reactions may occur (see below). The benefits do not outweigh the potential risks, … Tetrazepam
Products Chlordiazepoxide was synthesized in the 1950s by Leo Sternbach at Hoffmann-La Roche and became the first active ingredient in the benzodiazepine group to be marketed in 1960 (Librium). In many countries, it is currently only available in combination with clidinium bromide or amitriptyline (Librax, Limbitrol). In other countries, the monopreparation Librium is still available. … Chlordiazepoxide
Products Alprazolam is commercially available as tablets, sustained-release tablets, and sublingual tablets (Xanax, generics). It has been approved in many countries since 1980. “Xanax” is a palindrome and remains the same when read forwards or backwards. Structure and properties Alprazolam (C17H13ClN4, Mr = 308.7 g/mol) exists as a white crystalline powder that is practically insoluble … Alprazolam
Products No medicines containing delorazepam are registered in many countries. In Italy, products available include EN drops and tablets and generics. Structure and properties Delorazepam (C15H10Cl2N2O, Mr = 305.2 g/mol) is a chlorinated and demethylated diazepam (Valium) related to lorazepam (Temesta). Effects Delorazepam (ATC N05BA) has antianxiety, sedative, anticonvulsant, and sleep-inducing properties. It crosses the … Delorazepam
