Products Azacitidine is commercially available as a lyophilizate for the preparation of a suspension for injection (Vidaza, generic). It has been approved in many countries since 2006. Structure and properties Azacitidine (C8H12N4O5, Mr = 244.2 g/mol) is a derivative of the nucleoside cytidine found in nucleic acids. It belongs to the pyrimidine nucleoside analogues. Azacitidine … Azacitidine
Products 5-Fluorouracil is commercially available as an ointment (Efudix), as a topical solution in combination with salicylic acid (Verrumal), and in preparations for parenteral administration. This article refers to topical application. In 2011, 5-fluorouracil at the lower concentration of 0.5% was approved in many countries with Actikerall. Structure and properties 5-Fluorouracil (C4H3FN2O2, Mr = 130.08 … 5-Fluorouracil
Products Gemcitabine is commercially available as a lyophilizate for the preparation of an infusion solution (Gemzar, generics). It has been approved in many countries since 1997. Structure and properties Gemcitabine (C9H11F2N3O4, Mr = 263.2 g/mol) is present in drugs as gemcitabine hydrochloride, a white substance that is soluble in water. The pyrimidine gemcitabine is a … Gemcitabine
Poducts Mercaptopurine is commercially available in tablet and oral suspension form (Puri-Nethol, Xaluprine). The active ingredient has been approved in many countries since 1955. Structure and properties Mercaptopurine (C5H4N4S – H2O, Mr = 170.2 g/mol) exists as a yellow crystalline powder that is practically insoluble in water. It is an analog of the purine bases … Mercaptopurine
Products Tioguanine is commercially available in tablet form (Lanvis). It has been approved in many countries since 1973. Structure and properties Tioguanine (C5H5N5S, Mr = 167.2 g/mol) is a 6-thiol analog of guanine. Effects Tioguanine (ATC L01BB03) has cytotoxic properties as a purine antimetabolite. Indications For the treatment of acute myeloid leukemia. Other indications include … Tioguanin
Products Fludarabine is commercially available as an injection/infusion preparation (generic, original: Fludara). It was approved in the United States in 1991 and in many countries in 1995. Structure and properties Fludarabine (C10H12FN5O4, Mr = 285.2 g/mol) or 9-β-D-arabinosyl-2-fluoroadenine is present in drugs as fludarabine phosphate, a white, crystalline, hygroscopic powder that is sparingly soluble in … Fludarabine
Products Clofarabine is commercially available as a concentrate for the preparation of an infusion solution (Evoltra). The drug is not registered in many countries. Structure and properties Clofarabine (C10H11ClFN5O3, Mr = 303.7 g/mol) is a purine derivative. Effects Clofarabine (ATC L01BB06) is antitumoral and cytotoxic. Indications Acute lymphoblastic leukemia (ALL) in pediatric patients.
