Products Velaglucerase alfa is commercially available as a powder for the preparation of an infusion solution (Vpriv). It has been approved in many countries since 2011. Structure and properties Velaglucerase alfa is an enzyme and glycoprotein with 497 amino acids and the same sequence as natural glucocerebrosidase. Glycosylation with mannose results in velaglucerase alfa being … Velaglucerase Alfa
Products Rasburicase is commercially available as an injectable (Fasturtec). It has been approved in many countries since 2002. Structure and properties Rasburicase is a recombinant urate oxidase enzyme produced by a genetically modified strain of yeast. Effects The enzyme rasburicase (ATC V03AF07) catalyzes the enzymatic oxidation of uric acid into allantoin, a water-soluble substance that, … Rasburicase
Products Sebelipase alfa was approved in the EU and US in 2015 and in many countries in 2016 as a concentrate for the preparation of an infusion solution (Kanuma). Structure and properties Sebelipase alfa is a recombinant human lysosomal acid lipase (rhLAL) with the same amino acid sequence as the endogenous enzyme. The protein is … Sebelipase Alfa
Products Taliglucerase alfa is commercially available as an infusion preparation in some countries (Elelyso). It has not yet been registered in many countries. Structure and properties Taliglucerase alfa is an enzyme and an analog of natural glucocerebrosidase, from which it differs in several amino acids. Glycosylation with mannose results in the uptake of taliglucerase alfa … Taliglucerase Alfa
Products Dornase alfa is commercially available as an inhalation solution (Pulmozyme). It has been approved in many countries since 1994. Structure and properties Dornase alfa is a genetically engineered variant of the enzyme human deoxyribonuclease I, which occurs naturally in humans. Effects Dornase alfa (ATC R05CB13) has mucolytic properties. It cleaves extracellular DNA in the … Dornase Alfa
Products Glucarpidase is commercially available in the United States as an injectable (Voraxaze). The drug has not yet been approved in many countries. Structure and properties Glucarpidase is a carboxypeptidase biotechnologically derived from genetically modified. It is protein composed of 390 amino acids and exists as a homodimer with a molecular weight of 83 kDa. … Glucarpidase
Products Cerliponase alfa was approved in the United States in 2017 as a solution for injection (Brineura). The drug’s extremely high price is controversial. Structure and properties Cerliponase alfa is a recombinant tripeptidyl peptidase 1 (rhTPP1) produced by biotechnological methods. Effects Cerliponase alfa replaces the insufficiently active enzyme tripeptidyl peptidase 1 (TPP1) in patients with … Cerliponase Alfa
Products Imiglucerase is commercially available as a powder for the preparation of an infusion solution (Cerezyme). It has been approved in many countries since 1999. Structure and properties Imiglucerase is an enzyme produced by biotechnological methods. The glycoprotein consists of 497 amino acids. The sequence differs in one amino acid from the natural acid beta-glucocerebrosidase. … Imiglucerase
Products Agalsidase is commercially available as an infusion preparation and has been approved in many countries since 2001 and 2003, respectively: Replagal: agalsidase alfa Fabrazyme: agalsidase beta Structure and properties Agalsidase is a recombinant human α-galactosidase A produced by biotechnological methods. The amino acid sequence is identical to the natural lysosomal enzyme. It is a … Agalsidase
