Werlhof’s Disease: Or something else? Differential Diagnosis

Blood, hematopoietic organs-immune system (D50-D90).

  • Thrombocytopenia of other cause such as immune thrombocytopenia (idiopathic thrombocytopenic purpura (ITP); synonyms: Immune thrombocytopenia; purpura haemorrhagica; thrombocytopenic purpura; autoimmune thrombocytopenia; immune thrombocytopenic purpura; mainly affects children), HUS (synonym: Gasser syndrome – rare disease mainly affecting infants and young children. One speaks of complete enteropathic HUS in the presence of microangiopathic hemolytic anemia (anemia) and thrombocytopenia (reduction in platelets) and renal insufficiency / renal failure), etc.
  • Hypersplenism – complication of splenomegaly; leads to an increase in functional capacity beyond what is necessary; as a result, there is excessive elimination of erythrocytes (red blood cells), leukocytes (white blood cells) and platelets (platelets) from the peripheral blood, resulting in pancytopenia (synonym: tricytopenia: decrease in blood cells of all systems).

Infectious and parasitic diseases (A00-B99).

  • Infections, unspecified
  • HIV infection

Musculoskeletal system and connective tissue (M00-M99).

Neoplasms – tumor diseases (C00-D48).

  • Chronic lymphocytic leukemia (CLL) – malignant neoplasm of the hematopoietic system (hemoblastosis).
  • Malignant lymphoma (malignant neoplasm originating in the lymphatic system), predominantly associated with Hodgkin’s disease (malignant neoplasm (malignant neoplasm) of the lymphatic system with possible involvement of other organs)

Drugs that can lead to isolated thrombocytopenia:

  • Abciximab – drug from the group of monoclonal antibodies; acts as an antiplatelet (anticoagulant).
  • Aciclovir (antiviral) – active substance against viral infections.
  • Aminosalicylic acid (mesalazine) – active ingredient used in chronic inflammatory bowel diseases.
  • Amiodarone (antiarrhythmic drug ) – active substance against cardiac arrhythmias.
  • Amphotericin B (antifungal) – active substance against fungal infections.
  • Ampicillin (antibiotic) – active substance against bacterial infections.
  • Carbamazepine (anti-epileptic)
  • Chlorpropamide (antidiabetic) – active substance used in diabetes mellitus (diabetes).
  • Danazol (androgen)
  • Diatrizoate (X-ray contrast agent)
  • Diclofenac (analgesic/painkiller)
  • Digoxin (cardiac glycoside) – active substance, which is used in cardiac insufficiency and cardiac arrhythmias.
  • Eptifibatide – active substance from the group of platelet aggregation inhibitors (anticoagulants).
  • Heparin (anticoagulant)
  • Hydrochlorothiazide (HCT) (diuretic) – dehydrating drug.
  • Ibuprofen (analgesic / painkiller)
  • Levamisole (immunomodulator)
  • Octreotide (somatostatin analogue)
  • Paracetamol (analgesic/pain reliever).
  • Phenytoin (antiepileptic drugs) – active substance from the group of antiepileptic drugs.
  • Quinine (antimalarials)
  • Rifampicin (antibacterial agent from the group of tuberculostatics ) – active substance against tuberculosis.
  • Tamoxifen (antiestrogen)
  • Tirofiban – active substance from the group of antiplatelet agents (anticoagulants).
  • Trimethoprim / sulfamethoxazole (antibiotics) – combination of active ingredients against bacterial infections.
  • Vancymycin (antibiotic) – active substance against bacterial infections.