Products Zidovudine is commercially available as film-coated tablets, capsules, and syrup (Retrovir AZT, combination products). It was approved in 1987 as the first AIDS drug. Structure and properties Zidovudine (C10H13N5O4, Mr = 267.2 g/mol) or 3-azido-3-deoxythymidine (AZT) is an analog of thymidine. It exists as an odorless, white to beige, crystalline substance that is soluble … Zidovudine (AZT)
Products Stavudine is commercially available in capsule form (Zerit). It has been approved in many countries since 1996. Structure and properties Stavudine (C10H12N2O4, Mr = 224.2 g/mol) is a thymidine analog with a missing 3′-hydroxy group. It is a prodrug that is biotransformed intracellularly to the active metabolite stavudine triphosphate. Stavudine exists as a white … Stavudine
Products Abacavir is commercially available as film-coated tablets and as an oral solution (Ziagen, combination products). It has been approved in many countries since 1999. Generic versions are approved. Structure and properties Abacavir (C14H18N6O, Mr = 286.3 g/mol) is present in drugs, among other forms, as abacavir sulfate, a white crystalline powder that is soluble … Abacavir
Products Efavirenz is commercially available as film-coated tablets and as an oral solution (Stocrin, combination products, generics). It has been approved in many countries since 2001. Structure and properties Efavirenz (C14H9ClF3NO2, Mr = 315.7 g/mol) exists as a white to light pink crystalline powder that is practically insoluble in water. It has a non-nucleoside structure … Efavirenz
Products Emtricitabine is commercially available as a monopreparation in the form of capsules and as an oral solution (Emtriva, combination products, generics). It has been approved in many countries since 2004. Structure and properties Emtricitabine (C8H10FN3O3S, Mr = 247.2 g/mol) is a thioanalog of cytidine with a fluorine atom at the 5-position. It exists as … Emtricitabine
Products Zalcitabine is not commercially available in many countries. Structure and properties Zalcitabine (C9H13N3O3, Mr = 211.2 g/mol) exists as a white crystalline powder that is soluble in water. Effects Zalcitabine (ATC J05AF03) is antiviral. It is an inhibitor of HIV reverse transcriptase. Indications HIV, combination antiretroviral therapy.
Products Nevirapine is commercially available in tablet and sustained-release tablet form (Viramune, generics). It has been approved in many countries since 1997. Structure and properties Nevirapine (C15H14N4O, Mr = 266.3 g/mol) exists as a white crystalline powder that is practically insoluble in water. It has a non-nucleoside structure. Effects Nevirapine (ATC J05AG01) has antiviral properties … Nevirapine
Products Etravirine is commercially available in tablet form (Intelence). It has been approved in many countries since 2008. Structure and properties Etravirine (C20H15BrN6O, Mr = 435.3 g/mol) is a brominated aminopyrimidine and a benzonitrile derivative. It exists as a white to slightly yellow-brown powder and is practically insoluble in water. Etravirine has a non-nucleoside structure … Etravirine
Products Didanosine was commercially available in the form of capsules (Videx EC). It was first approved in 1991 as the second HIV drug after AZT (EC = enteric coated, capsules filled with enteric granules). Structure and properties Didanosine (C10H12N4O3, Mr = 236.2 g/mol) corresponds to 2′,3′-dideoxyinosine, a synthetic nucleoside analog of deoxyadenosine. The 3′-hydroxy group … Didanosine
Products Doravirin was approved in the US and EU in 2018 and in many countries in 2019 in film-coated tablet form (Pifeltro). It is also combined with lamivudine and tenofovirdisoproxil fixed (Delstrigo). Structure and properties Doravirin (C17H11ClF3N5O3, Mr = 425.8 g/mol) is a pyridinone and triazole derivative that is practically insoluble in water. The drug … Doravirin
Products Rilpivirine has been commercially available in the EU and the United States since 2011 in tablet form (Edurant, combination products). In many countries, rilpivirine was approved in February 2013. Structure and properties Rilpivirine (C22H18N6, Mr = 366.4 g/mol) has a non-nucleoside structure. It is a diarylpyrimidine and is present in drugs as rilpivirine hydrochloride, … Rilpivirine
Products Lamivudine is commercially available as film-coated tablets and as an oral solution (3TC, generic, combination). It has been approved in many countries since 1996. Lamivudine is also administered for the treatment of chronic hepatitis B. This article refers to therapy for HIV. Generic medications are approved. Structure and Properties Lamivudine (C8H11N3O3S, Mr = 229.3 … Lamivudine
