Products Nalbuphine is commercially available as a solution for injection (Nalbuphine OrPha). It has been approved in many countries since 2004. Structure and properties Nalbuphine (C21H27NO4, Mr = 357.4 g/mol) is a morphine derivative structurally related to naloxone and oxymorphone. It is present in drugs as nalbuphine hydrochloride. Effects Nalbuphine (ATC N02AF02) has analgesic properties. … Nalbuphin
Products Remifentanil is commercially available as a powder for the preparation of a concentrate for solution for injection or infusion (Ultiva, generic). It has been approved in many countries since 1996. Structure and properties Remifentanil (C20H28N2O5, Mr = 376.4 g/mol) is present in drugs as remifentanil hydrochloride, a white powder. The drug is rapidly hydrolyzed … Remifentanil
Products Nicomorphine was commercially available in the form of tablets, suppositories, and as a solution for injection (Vilan). It had been approved in many countries since 1957. It was discontinued in 2015. Structure and properties Nicomorphine (C29H25N3O5, Mr = 495.5 g/mol), like heroin, is an ester as well as a nicotinic acid derivative of morphine … Nicomorphine
Products Fentanyl is commercially available in many countries in the form of lozenges, buccal tablets, sublingual tablets, as a fentanyl patch (e.g., Durogesic, generic), and as a solution for injection. It is a narcotic and is subject to enhanced prescription requirements. Structure and properties Fentanyl (C22H28N2O, Mr = 336.5 g/mol) exists as a white powder … Fentanyl: Drug Effects, Side Effects, Dosage and Uses
Products Fortalgesic (off label) Structure and properties Pentazocine (C19H27NO, Mr = 285.4 g/mol) Effects Pentazocine (ATC N02AD01) has analgesic properties. Indications For the treatment of pain.
Products Heroin (med. diamorphine) is commercially available as an injectable and in tablet form (Diaphin). It has been approved as a drug in many countries since 2001. Structure and properties Heroin is a diacetylated derivative of the opium ingredient morphine and belongs to the opioid group. It is present in drugs as diamorphine hydrochloride monohydrate … Heroin
Products Tilidine is commercially available as an oral solution (Valoron). It has been approved in many countries since 1975. In Germany, tilidine fix is combined with the opioid antagonist naloxone to prevent abuse (Valoron N). Structure and properties Tilidine (C17H23NO2, Mr = 273.4 g/mol) is present in drugs as tilidine hydrochloride hemihydrate, a racemate and … Tilidine
Products Sufentanil is commercially available as a solution for injection (Sufenta, generic). It was developed in the 1970s and has been approved in many countries since 1994. Sublingual tablets for pain management are also available in some countries (Dzuveo, Zalviso). Structure and properties Sufentanil (C22H30N2O2S, Mr = 386.6 g/mol) is present in drugs as sufentanil … Sufentanil
Products Piritramid is available in Germany and Austria as a solution for injection (Dipidolor). No drugs containing the active ingredient are approved in many countries. Structure and properties Piritramide (C27H34N4O, Mr = 430.6 g/mol) is a diphenylpropylamine derivative developed at Janssen. It is structurally related to pethidine and fentanyl. Effects Piritramide (ATC N02AC03) has analgesic … Piritramid
Products Medicines containing desomorphine are not available in many countries. Desomorphine is a narcotic subject to enhanced prescription (dispensing category A+). It was commercially available decades ago under the brand name Permonid (Roche). Structure and properties Desomorphine (C17H21NO2, Mr = 271.4 g/mol) is des-O-morphine, i.e., morphine lacking an oxygen. It is equivalent to morphine except … Desomorphine
Products Ethylmorphine was present in cough syrups. Structure and properties Ethylmorphine (C19H23NO_(3, Mr = 313.4 g/mol) is an -ethylated morphine. It is present in drugs as ethyl morphine hydrochloride and as a dihydrate, a white crystalline powder that is soluble in water. Effects Ethylmorphine (ATC R05DA01, ATC S01XA06) is an antitussive agent. Indications Irritative cough
Products Transdermal fentanyl has been approved in many countries since 1996 (Durogesic, generic). Various strengths are available. The larger the patch, the more fentanyl is released per unit time: 12 µg/h, 25 µg/h, 50 µg/h, 75 µg/h, and 100 µg/h. The opioid is legally classified as a narcotic. Structure and properties Fentanyl (C22H28N2O, Mr = … Fentanyl Patch
