Crohn's Disease

Crohn’s Disease: Symptoms, Complaints, Signs

The following symptoms and complaints may indicate the onset of Crohn’s disease: Abdominal pain (abdominal pain/abdominal tenderness) in the right lower abdomen and periumbilical (around the umbilicus) (approximately 80%) Diarrhea (about 70%), possibly with mucus admixtures; hemorrhagic diarrhea (bloody diarrhea), possibly with mucus admixtures (45% / 35%). Fatigue Growth retardation: weight stagnation (in children) or … Crohn’s Disease: Symptoms, Complaints, Signs

Crohn’s Disease: Causes

Pathogenesis (disease development) To date, it is not clear what causes Crohn’s disease. Genetic, familial, infectious, and immunologic causes are discussed. What is certain is a dysbalance of pro- and anti-inflammatory messenger substances. Among the proinflammatory (inflammation-promoting) cytokines, tumor necrosis factor (TNF) plays a key role. Etiology (causes) Biographic Causes Genetic burden Familial clustering – … Crohn’s Disease: Causes

Crohn’s Disease: Therapy

General measures Nicotine restriction (refraining from tobacco use); reduces the risk of relapse (risk of recurrence) by approximately 50% – participation in a smoking cessation program, if necessary. Limited alcohol consumption (men: max. 25 g alcohol per day; women: max. 12 g alcohol per day). Aim for normal weight!Determination of BMI (body mass index, body … Crohn’s Disease: Therapy