Hyperinsulinism

Hyperinsulinism: Test and Diagnosis

1st order laboratory parameters – obligatory laboratory tests. Fasting insulin [Homa index: see “Fasting insulin” below] C-peptide (part of proinsulin; indicator of beta cell function/insulin-producing cells in the islets of Langerhans of the pancreas (pancreas); decreased levels: including diabetes mellitus, starvation; increased levels: including insulinoma, metabolic syndrome, renal function impairment). Fasting glucose (fasting blood glucose). … Hyperinsulinism: Test and Diagnosis

Hyperinsulinism: Diagnostic Tests

Obligatory medical device diagnostics. Abdominal ultrasonography (ultrasound examination of the abdominal organs) – for basic diagnosis. Optional medical device diagnostics – depending on the results of the history, physical examination and obligatory laboratory parameters – for differential diagnostic clarification. Computed tomography (CT) of the abdomen (abdominal CT) – for further diagnosis of suspected neoplasms.

Hyperinsulinism: Prevention

To prevent hyperinsulinism, attention must be paid to reducing individual risk factors. Behavioral risk factors Diet High-carbohydrate diet (mainly of glucose and sucrose (sugar); e.g., also consumption of soft drinks with sugar). High-fat diet (saturated fat)Note: A flavored palm oil drink led to a reduction in insulin sensitivity or insulin resistance, as well as increased … Hyperinsulinism: Prevention

Hyperinsulinism: Symptoms, Complaints, Signs

The following symptoms and complaints may indicate hyperinsulinemia: Leading symptoms Chronic hypoglycemia (hypoglycemia; blood glucose concentration below the physiologic norm of 60 mg/dl or 3.3 mmol/l) [see below for classification of hypoglycemia by severity]. The signs of hypoglycemia depend on the degree of hypoglycemia. According to the severity of hypoglycemia, three groups are distinguished: Autonomic … Hyperinsulinism: Symptoms, Complaints, Signs

Hyperinsulinism: Therapy

Therapy for hyperinsulinemia depends on the cause. General measures Aim for normal weight!Determination of BMI (body mass index, body mass index) or body composition using electrical impedance analysis and, if necessary, participation in a medically supervised weight loss program. Review of permanent medication due topossible effect on the existing disease. Conventional non-surgical therapy methods In … Hyperinsulinism: Therapy

Hyperinsulinism: Causes

Pathogenesis (disease development) Hyperinsulinemia may be caused by increased secretion of insulin or by peripheral insulin resistance (= decreased or abolished action of the peptide hormone insulin in peripheral tissues). Tumors (insulinomas, rare mostly benign tumors) can also lead to an overproduction of insulin. A distinction is made between acquired hyperinsulinism and congenital hyperinsulinism. In … Hyperinsulinism: Causes

Hyperinsulinism: Or something else? Differential Diagnosis

Endocrine, nutritional, and metabolic diseases (E00-E90). Obesity (obesity) Autoantibodies against insulin Diabetes mellitus type 2 (age-related diabetes) – leads to peripheral insulin resistance (reduced effectiveness of endogenous insulin at target organs skeletal muscle, adipose tissue and liver). Ectopic insulin secretion – secretion of insulin from a site other than the pancreas (pancreas). Congenital hyperinsulinemia (CHI) … Hyperinsulinism: Or something else? Differential Diagnosis

Hyperinsulinism: Complications

The following are the most important diseases or complications that may be contributed to by hyperinsulinism: Endocrine, nutritional, and metabolic diseases (E00-E90). Obesity (obesity) Hypernatremia (excess sodium → volume expansion). Hypoglycemic coma – severe disturbance of consciousness induced by hypoglycemia. Hypokalemia (potassium deficiency). Cardiovascular system (I00-I99) Atherosclerosis (arteriosclerosis, hardening of the arteries) is forced by … Hyperinsulinism: Complications

Hyperinsulinism: Examination

A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; further: Inspection Skin, mucous membranes, and sclerae (white part of the eye) [Autonomic signs (synonym: adrenergic signs) – these result from reactive adrenaline release. These signs include: Paleness Ravenous hunger Sweating Tremor … Hyperinsulinism: Examination

Hyperinsulinism: Medical History

Medical history (history of illness) represents an important component in the diagnosis of hyperinsulinemia. Family history Social history Current anamnesis/systemic anamnesis (somatic and psychological complaints). What symptoms have you noticed? Are you experiencing dizziness, weakness, cravings, nausea, sweating, and/or impaired consciousness* ? Do you suffer from palpitations and heart palpitations? How long has this symptomatology … Hyperinsulinism: Medical History