Silymarin (Milk Thistle Fruit Extract): Safety Evaluation

No adverse effects have been reported in clinical intervention studies conducted to date. In animal studies, oral intake of a maximum of 2,500 to 5,000 mg/kg silymarin has been shown to be nontoxic and symptom-free. Caution should be exercised in cases of hypersensitivity to the active ingredient and other plants of the genus Asteraceae (or … Silymarin (Milk Thistle Fruit Extract): Safety Evaluation

Silymarin (Milk Thistle Fruit Extract): Interactions

There are moderate interactions between silymarin and drugs that are metabolized (metabolized) in the liver via cytochromes P450 2C9. Concomitant use of silymarin and these drugs may slow their breakdown and increase their effects and side effects. Furthermore, there are interactions between milk thistle and glucuronidated drugs. In this case, the effect of the drugs … Silymarin (Milk Thistle Fruit Extract): Interactions

Silymarin (Milk Thistle Fruit Extract): Functions

Traditionally, silymarin has been used as a tea or dry extract to treat diseases of the liver, gallbladder, and spleen. It is now one of the best-studied phytochemicals.Based on clinical data, silymarin is used supportively for the following conditions: Alcohol-related liver disease Cirrhosis of the liver Acute and chronic hepatitis Liver disease induced by drugs, … Silymarin (Milk Thistle Fruit Extract): Functions