Effects of genistein: Weak estrogenic effect – estrogenic activity is one-third that of glycitein and four times more active than daidzein. Anticarcinogenic effect – genistein inhibits cell proliferation of various tumor cells, especially in the prostate, by promoting apoptosis (programmed cell death). Inhibition of topoisomerase II – this enzyme is able to cleave DNA and … Genistein: Functions
Interactions of isoflavones with other agents (micronutrients, foods, drugs): Drug tamoxifen Interactions of isoflavones, particularly genistein, with tamoxifen (a selective estrogen receptor modulator used as a drug for adjuvant antihormonal therapy of breast carcinoma/breast cancer when this is estrogen receptor positive) have been reported in the literature. When administered concomitantly, isoflavones may reverse the effect … Genistein: Interactions
Intake recommendations of the German Nutrition Society (DGE) are not yet available for genistein. Genistein content – given in µg – per 100 g food. Cereal products Nuts and seeds Barley 7,70 Sunflower seeds 13,90 Peanuts 15,80 Fruit Hazelnuts 18,47 Passion fruit 1,08 Honeydew melon 1,13 Soy and soy products Clementines 2,90 Soy infant milk … Genistein: Food
Animal studies are contradictory in their conclusions about the intake of soy isoflavones: Some studies showed that in an existing breast carcinoma (tumor of the mammary gland tissue), isoflavones can accelerate the growth of tumor cells. In studies on mice, the administration of isolated genistein in existing breast cancer led to increased spread of tumor … Genistein: Safety Assessment
