Products
The drug used to prevent HIV with medication (pre-exposure prophylaxis, PrEP) is available in the form of film-coated tablets (Truvada). PrEP is short for pre-exposure prophylaxis.
Structure and properties
The following antiviral agents are contained in the drug product:
- Emtricitabine (200 mg)
- Tenofovirdisoproxil (245 mg)
Effects
Both ingredients (ATC J05AR03) have antiviral properties. They are reverse transcriptase inhibitors (NRTIs). They inhibit the viral enzyme reverse transcriptase, which transcribes viral RNA into DNA and is important for viral replication.
Indications
In combination with safer sex practices for preexposure prophylaxis to reduce the risk of sexually acquired HIV-1 infection for persons at high risk.
Dosage
According to the SmPC. Tablets are taken once daily with a meal.
Contraindications
- Hypersensitivity
- Use for PrEP in individuals with unknown or positive HIV-1 status.
Full details of precautions and interactions can be found in the drug label.
Adverse effects
The most common possible adverse effects include headache, abdominal pain, and weight loss.