Hypertriglyceridemia: Or something else? Differential Diagnosis

Endocrine, nutritional, and metabolic diseases (E00-E90).

  • Obesity (obesity).
  • Acromegaly – increase in size of body end limbs due to increased presence of growth hormone after completion of growth.
  • Cushing’s disease/Cushing’s syndrome – disease in which a tumor in the ACTH-producing cells of the pituitary gland produces too much ACTH, resulting in increased stimulation of the adrenal cortex and, as a consequence, excessive cortisol production.
  • Diabetes mellitus (diabetes).
  • Glycogen storage diseases, unspecified.
  • Hyperuricemia/gout
  • Lipodystrophy (fat tissue atrophy)

Mixed hyperlipidemia

  • Hyperbetalipoproteinemia with prebetalipoproteinemia.
  • Hypercholesterolemia with endogenous hypertriglyceridemia.
  • Hyperlipidemia, group C
  • Hyperlipoproteinemia type IIb or III according to Fredrickson
  • Lipoproteinemia with a broad beta band
  • Tubo-eruptive xanthoma (a xanthoma is a skin lesion resulting from increased storage of plasma lipoproteins in the skin in the setting of hyperlipoproteinemia)
  • Xanthoma tuberosum

Pure hypertriglyceridemia

  • Endogenous hypertriglyceridemia
  • Hyperlipidemia, group B
  • Hyperlipoproteinemia type IV according to Fredrickson
  • Hyperlipoproteinemia of the very-low-density-lipoprotein type (VLDL).
  • Hyperprebetalipoproteinemia

Infectious and parasitic diseases (A00-B99).

  • Sepsis (blood poisoning)

Liver, gallbladder, and bile ducts-pancreas (pancreas) (K70-K77; K80-K87).

  • Cholestasis (biliary stasis)
  • Hepatitis (inflammation of the liver), unspecified

Psyche – nervous system (F00-F99; G00-G99)

  • Alcohol abuse (alcoholism)
  • Stress

Pregnancy, childbirth and puerperium (O00-O99)

  • Pregnancy

Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99)

  • Nephrotic syndrome – collective term for symptoms that occur in various diseases of the glomerulus (renal corpuscles); symptoms include: Proteinuria (increased excretion of protein in urine) with protein loss greater than 1 g/m²/body surface area per day; hypoproteinemia, peripheral edema due to serum hypalbuminemia of < 2.5 g/dL, hyperlipoproteinemia (dyslipidemia).
  • Renal insufficiency (kidney weakness).

Further

  • Regular alcohol consumption (woman: > 20 g/day; man > 30 g/day).

Medication

  • See “Causes” under medications

Notice. See for other secondary hyperlipoproteinemias (= consequences of other underlying diseases) under Classification (under the topic of the same name).