Hyperlipoproteinemia

Lipoprotein(a) Elevation (Hyperlipoproteinemia): Drug Therapy

Therapeutic Targets Reduction of severely elevated lipoprotein levels in the future possible by antisense therapy). Treatment of concomitant hyperlipoproteinemias (lipid metabolic disorders). Therapy recommendations Therapy of hyperlipoproteinemia (in this case: Lipoprotein(a) elevation) is based on the following pillars: Secondary prevention, that is, reduction of risk factors [no effect on lipoprotein(a) elevation]. Micronutrient therapy (vital substances; … Lipoprotein(a) Elevation (Hyperlipoproteinemia): Drug Therapy

Lipoprotein(a) Elevation (Hyperlipoproteinemia): Micronutrient Therapy

In the context of micronutrient medicine (vital substances), the following vital substance (micronutrients) is used for supportive therapy: L-carnitine The above vital substance recommendations (micronutrients) were created with the help of medical experts. All statements are supported by scientific studies with high levels of evidence. For a therapy recommendation, only clinical studies with the highest … Lipoprotein(a) Elevation (Hyperlipoproteinemia): Micronutrient Therapy

Lipoprotein(a) Elevation (Hyperlipoproteinemia): Prevention

To prevent lipoprotein (a) elevation, attention must be paid to reducing individual risk factors. Behavioral Causes High intake of trans fatty acids (10-20 g/day; eg, baked goods, chips, fast-food products, convenience foods, fried foods such as French fries, breakfast cereals with added fat, snacks, confectionery, dry soups). Drugs that increase lipoprotein (a). Growth hormone (STH)

Lipoprotein(a) Elevation (Hyperlipoproteinemia): Treatment

Therapy for hyperlipoproteinemia (here: Lipoprotein (a) elevation) is based on the following pillars: Secondary prevention, that is, reduction of risk factors. Drug therapy Micronutrient therapy (vital substances) Operative therapy Other therapy Lifestyle modification The treatment modality for hyperlipoproteinemia depends on the level of LDL measured and the risk factors the individual has: Risk group LDL … Lipoprotein(a) Elevation (Hyperlipoproteinemia): Treatment

Lipoprotein(a) Elevation (Hyperlipoproteinemia): Causes

Pathogenesis (disease development) The level of serum lipoprotein (a) is genetically determined (see below).The structure of lipoprotein (a) is similar to that of cholesterol. Because plasminogen (a nonactive proenzyme in the fibrinolysis factor group) also has this property, lipoprotein (a) is suspected to exert atherosclerotic effects via enhancement of the action of plasminogen. Etiology (Causes) … Lipoprotein(a) Elevation (Hyperlipoproteinemia): Causes

Lipoprotein(a) Elevation (Hyperlipoproteinemia): Therapy

General measures Adjustment of existing underlying diseases to optimal levels Aim for normal weight! Determination of BMI (Body Mass Index, body mass index) or body composition by means of electrical impedance analysis and, if necessary, participation in a medically supervised weight loss program. Nicotine restriction (refrain from tobacco use). Limited alcohol consumption (men: max. 25 … Lipoprotein(a) Elevation (Hyperlipoproteinemia): Therapy

Hypertriglyceridemia: Therapy

General measures Adjustment of existing underlying diseases to optimal levels (see “Drug therapy“). Increase physical activity to 2.5-5 hours per week of moderate aerobic exercise or 1.25-2.5 hours per week of intense aerobic exercise. Aim for normal weight! Determination of BMI (body mass index, body mass index) or body composition by means of electrical impedance … Hypertriglyceridemia: Therapy

Lipoprotein(a) Elevation (Hyperlipoproteinemia): Medical History

Medical history (history of the patient) represents an important component in the diagnosis of hyperlipoproteinemia (lipoprotein (a)-elevation or -decrease (hyperlipoproteinemia). Family History Is there a frequent history of dyslipidemia in your family? Are there any hereditary diseases in your family? Social history Is there any evidence of psychosocial stress or strain due to your family … Lipoprotein(a) Elevation (Hyperlipoproteinemia): Medical History

Apolipoproteins

Apolipoproteins are the protein portion of lipoproteins that transports water-insoluble lipids in the blood. The following forms of apolipoproteins can be distinguished: Apolipoprotein A1 (apo A1; APOA1). Apolipoprotein A2 (apo A2; APOA2) Apolipoprotein B (apo B; APOB) Apolipoprotein B-100 (apo B-100; APOB-106) Apolipoprotein E (apo E; APOE) Apolipoprotein E isoforms Different lipoproteins are occupied by … Apolipoproteins

Lipoprotein(a) Elevation (Hyperlipoproteinemia): Or something else? Differential Diagnosis

Endocrine, nutritional, and metabolic diseases (E00-E90). Acromegaly – increase in size of body end limbs due to increased presence of growth hormone after cessation of growth. Hypothyroidism (underactive thyroid gland). Infectious and parasitic diseases (A00-B99). Inflammation, unspecified Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99). Nephrotic syndrome – collective term for symptoms that occur … Lipoprotein(a) Elevation (Hyperlipoproteinemia): Or something else? Differential Diagnosis