1st-order laboratory parameters-obligatory laboratory tests.
- Parathyroid hormone (PTH intact) [↓]
- Electrolytes
- Calcium [in serum ↓; in urine ↓]
- Magnesium [in serum ↓]
- Phosphate [in serum ↑; in urine ↓]
- CAMP (cyclic adenosine monophosphate) [in urine ↓]
Further notes
- Primary hypoparathyroidism is considered highly probable when hypocalcemia (calcium deficiency) and hyperphosphatemia (phosphate excess) have been demonstrated with normal creatinine (metabolite excreted in urine (urinary)) and normal albumin levels (exclusion of malassimilation syndrome/impaired nutrient utilization due to decreased breakdown and/or absorption). Ultimately, a decreased parathyroid hormone level confirms the diagnosis.
- If pseudohypoparathyroidism is suspected, the Ellsworth-Howard test is recommended: after the administration of PTH, there is an increase in phosphate in the urine of a healthy person to more than twice the initial value. If there is a pseudohypoparathyroidism, the increase is less.
- Autoimmune polyendocrinopathy type I, or APECED syndrome (autoimmune polyendocrinopathy – candidiasis – ectodermal dystrophy), is a genetic disease that manifests in childhood or early adolescence with a combination of chronic mucocutaneous candidiasis, hypoparathyroidism, and autoimmune adrenal insufficiency (adrenal weakness) (see. u. www.orha.net); mode of inheritance: autosomal recessive; age of manifestation: childhood.
