Products
Isoconazole is commercially available as a cream (Travogen, Travocort + diflucortolone valerate). It has been approved in many countries since 1980. The ovules are out of commerce.
Structure and properties
Isoconazole (C18H14Cl4N2O, Mr = 416.1 g/mol) is present in drugs as a racemate and as isoconazole nitrate, a white powder that is very sparingly soluble in water. It is an imidazole and dichlorophenyl derivative. Isoconazole is structurally closely related to econazole (pevaryl).
Effects
Isoconazole (ATC D01AC05, ATC G01AF07) has antifungal properties against dermatophytes, yeasts, yeast-like fungi, and molds. The effects are due to inhibition of the synthesis of ergosterol, which is essential for the fungal cell membrane.
Indications
For the treatment of fungal skin infections.
Dosage
According to the package leaflet. The cream is applied twice a day. As with other azole antifungals, treatment should be continued for about two weeks after healing.
Contraindications
Isoconazole is contraindicated in hypersensitivity. Full precautions can be found in the drug label.
Interactions
No drug-drug interactions are known with topical use.
Adverse effects
Possible adverse effects include local reactions such as itching, burning, redness, blistering, and hypersensitivity reactions.
