Products Oxiconazole was commercially available in the form of vaginal tablets (Oceral). It was approved in many countries since 1983. It was discontinued in 2017. Structure and properties Oxiconazole (C18H13Cl4N3O, Mr = 429.1 g/mol) is present in drugs as oxiconazole nitrate. It is an imidazole derivative. Effects Oxiconazole (ATC D01AC11, ATC G01AF17) has antifungal properties … Oxiconazole
Products Amorolfine is commercially available for the treatment of a nail fungus as a nail polish (Loceryl, Curanel, 5%, generic). It has been approved in many countries since 1991. Curanel was released in April 2011 and, unlike Loceryl, is available without a doctor’s prescription. It is also sold as Curanail in other countries. In 2014, … Amorolfine
Products Amphotericin B is available in tablet, lozenge, suspension, and injection forms (Ampho-Moronal, Fungizone). It has been approved in many countries since 1964. This article refers to its use in the mouth and digestive system. Structure and properties Amphotericin B (C47H73NO17, Mr = 924 g/mol) is a mixture of antifungal polyenes obtained from certain strains … Amphotericin B: Effects and Side Effects
Products Caspofungin must be administered as an infusion solution because of its low oral bioavailability (Cancidas, generics). It has been approved in many countries since 2002 and was the first member of the echinocandins. Structure and properties Caspofungin is present in drugs as caspofungin diacetate (C52H88N10O15 – 2C2H4O2, Mr = 1213.42 g/mol), a hygroscopic white … Caspofungin
Products Nystatin is commercially available as a monopreparation as an oral suspension (Mycostatin, Multilind). Combination preparations are also available. Nystatin has been approved in many countries since 1967. Structure and properties Nystatin (C47H75NO17, Mr = 926 g/mol) is a fungicidal substance obtained from certain strains of by fermentation. It consists largely of tetraenes, the major … Nystatin: Drug Effects, Side Effects, Dosage and Uses
Products Clotrimazole is commercially available as creams, creams, ointments, sprays, vaginal tablets, and vaginal creams alone or in combination with other active ingredients (e.g., Canesten, Gyno-Canesten, Imacort, Imazol, Triderm). It has been approved in many countries since 1973. Structure and properties Clotrimazole (C22H17ClN2, Mr = 344.8 g/mol) is a chlorinated phenylmethylimidazole derivative. It exists as … Clotrimazole
Products Ketoconazole has been approved in many countries since 1981 and is now only commercially available as a shampoo and as a cream for external treatment (Nizoral, generics). Nizoral tablets were taken off the market in 2012 due to declining demand. This article refers to external use. Structure and properties Ketoconazole (C26H28Cl2N4O4, Mr = 531.4 … Ketoconazole
Products Anidulafungin is commercially available as a powder for the preparation of an infusion solution (Ecalta, generics). It has been approved in many countries since 2009. Structure and properties Anidulafungin (C58H73N7O17, Mr = 1140.3 g/mol) is a cyclic lipopeptide. It is a semisynthetic echinocandin obtained from a fermentation product of . It exists as a … Anidulafungin
Products Isavuconazonium sulfate is commercially available as a powder for a concentrate for the preparation of an infusion solution and in capsule form (Cresemba). It was approved in the US and EU in 2015 and in many countries in 2017. Structure and properties Isavuconazonium sulfate (C35H35F2N8O5S+ – HSO4– Mr = 814.8 g/mol) is a prodrug … Isavuconazonium Sulfate
Products Isoconazole is commercially available as a cream (Travogen, Travocort + diflucortolone valerate). It has been approved in many countries since 1980. The ovules are out of commerce. Structure and properties Isoconazole (C18H14Cl4N2O, Mr = 416.1 g/mol) is present in drugs as a racemate and as isoconazole nitrate, a white powder that is very sparingly … Isoconazole
Products Naftifine is commercially available as a gel and cream for external use. The drug has not yet been registered in many countries. Structure and properties Naftifine (C21H21N, Mr = 287.4 g/mol) is a lipophilic naphthalene derivative and belongs to the group of allylamines, which includes terbinafine. In pharmaceuticals, it is present as naftifine hydrochloride. … Naftifine
Products In 2009, a water-soluble varnish containing 8% ciclopirox was approved in many countries for the treatment of nail fungus, which is applied once daily (Ciclopoli). It went on sale in January 2011. In many countries, ciclopirox 8% had already been approved for the treatment of nail fungus for a number of years, in France … Ciclopirox against Nail Fungus
