Pathogenesis (disease development)
The pathogenesis of membranoproliferative glomerulonephritis is not fully understood. Immune complexes are thought to be deposited in different areas of the kidney, subendothelially (type I) or intramembranously (type II). A primary form can be distinguished from a secondary form. In the primary form, no underlying disease can be diagnosed.
Etiology (causes)
Behavioral causes
- Heroin use
Causes related to disease
- Autoimmune diseases such as systemic lupus erythematosus (SLE).
- Endocarditis (inflammation of the inner lining of the heart)
- Hepatitis B or C (inflammation of the liver)
- Liver cirrhosis – nodular liver remodeling with loss of function.
- Leukemia (blood cancer)
- Visceral abscess – abscess in the abdominal cavity.
