MEST (Oxford) classification of IgA nephropathy (IgAN).
The Oxford classification of IgA nephropathy is based on four histologic (“fine tissue”) parameters (MEST) to be evaluated biopsy. For evaluation, at least 8 glomuerula (singular: Glomerulus; vascular loops located in the renal cortex and inverted into Bowman’s capsule) must be present in the biopsy (tissue sample).
| Mesangial hypercellularity | |
| In ≤ 50% of glomeruli | M0 |
| In >50% of glomeruli | M1 |
| Endocapillary hypercellularity | |
| Absent | E0 |
| Available | E1 |
| Segmental glomerulosclerosis | |
| Absent | S0 |
| Available | S1 |
| Tubular atrophy/interstitial fibrosis | |
| 0-25% of the area of the renal cortex | T0 |
| 26-50% of the area of the renal cortex | T1 |
| > 50% of the area of the renal cortex | T2 |