Side effects

Side effects that affect the whole body are very rare and are actually only known in cases of significant overdose. In this case allergic reactions and circulation problems may occur. More common are local reactions, which include redness, swelling, burning and itching.

Interactions with other drugs are rather rare, but can occur with CYP3A4 inhibitors and antiarrhythmics. In case of side effects, a doctor should be consulted to discuss further treatment. Local allergic reactions to lidocaine patches occur regularly.

Those affected report itching, redness and burning in the area of the patch. However, it should be remembered that an allergic reaction to the patch adhesive may also be present. Systemic allergies up to allergic shock are rare, but can occur especially if the dose is too high. Allergic shock can cause swelling and irritation of many mucous membranes and thus also swelling of the respiratory tract.

Effect of Lidocaine patches

Lidocaine is a poorly water-soluble but highly liposoluble agent and can therefore be easily absorbed through the skin. Lidocaine travels to the nerves located in the subcutis and is deposited in the cell membrane.Normally the cell membrane is permeable to sodium and other electrolytes through different channels. The concentrations of the electrolytes create an action potential, which is transmitted to the brain.

In the brain, sensations and pain are consciously perceived. The lidocaine blocks the sodium channels in the cell membrane and thus prevents the development of an action potential. The transmission of pain to the brain is prevented.

Since nerve fibers for different sensations have different thicknesses and sheaths, only the sensation of pain is switched off at an appropriate dosage, and only at a higher dosage is the sensation of temperature and pressure also switched off. Lidocaine is gradually broken down and removed from the membrane, so the effect is not long-lasting. In the patches, it only penetrates the upper layers of the skin and does not work in the depths. Due to the low absorption into the bloodstream, a central effect on other parts of the body is not possible.