Products
Spasmo-Canulase Bitabs (originally Wander, then Sandoz, Novartis, GSK) went on sale in many countries in 1964. In 2017, distribution was discontinued for production reasons. Procurement of the seven active ingredients apparently became increasingly difficult.
Ingredients
In the fast-dissolving shell of the tablets:
- Metixene (anticholinergic).
- Pepsin (digestive enzyme)
- Dimethicone (defoamer)
- Glutamic acid hydrochloride (acid)
In the enteric core of the tablets:
- Pancreatin with the digestive enzymes amylase, lipase and protease.
- Cellulase (digestive enzyme)
- Dehydrocholic acid, as sodium salt (bile salt).
The tablets were slightly pink in color with erythrosine.
Effects
Spasmo-canulase has digestive, choleretic, antispasmodic, anticholinergic, and carminative properties.
Indications
Spasmo-Canulase has been used for gastrointestinal disorders with indigestion, abdominal pain, cramps, and flatulence:
- Irritable colon with flatulence, bloating, diffuse or colicky abdominal pain.
- Meteorism in ferment deficiency, aerophagy, fermentation and putrefaction dyspepsia.
- Dyspepsia after biliary disease, nervous indigestion.
Dosage
According to the professional information. The tablets were taken with meals.
Contraindications
- Hypersensitivity
- Narrow-angle glaucoma
- Prostate enlargement with micturition disorders
- Intestinal atony
- Myasthenia gravis
- Obstruction of the bile ducts
- Liver inflammation in the acute stage (acute hepatitis).
- Severe liver dysfunction
- Gallbladder empyema
- Coma hepaticum
For complete precautions, see the drug label.
Adverse effects
Possible adverse effects include dry mouth, urinary retention, visual disturbances, rapid pulse, palpable heartbeats, dilated pupils, and accommodative disturbances. These are due to the anticholinergic drug metixen.
