The following are the most important diseases or complications that may be contributed to by syphilis:
Eyes and eye appendages (H00-H59).
- Iritis (inflammation of the iris).
- Optic neuritis (optic neuritis).
- Uveitis – inflammation of the middle eye skin.
Skin – subcutaneous (L00-L99)
- Skin ulcerations (ulcers) on the soles of the feet.
Cardiovascular system (F00-F99; G00-G99).
- Aortic aneurysm – bulging of the wall of the aorta.
- Aortitis – inflammation of the aorta.
- Apoplexy (stroke)
- Hypertension (high blood pressure)
- Coronary sclerosis – calcification of the coronary arteries.
Liver, gallbladder and bile ducts – Pancreas (pancreas) (K70-K77; K80-K87).
- Hepatitis (inflammation of the liver)
Mouth, esophagus (esophagus), stomach, and intestines (K00-K67; K90-K93).
- Ulcerative colitis – inflammatory bowel disease (IBD).
- Gastritis (inflammation of the gastric mucosa)
- Proctitis (rectal inflammation)
Musculoskeletal system and connective tissue (M00-M99)
- Arthritis (inflammation of the joints)
- Joint destruction
- Periostitis – inflammation of the periosteum.
Psyche – nervous system (F00-F99; G00-G99)
- Brain-organic psychosyndrome
- Paresis (paralysis), e.g. facial paresis (in late syphilis).
Genitourinary system (kidneys, urinary tract – sex organs) (N00-N99).
- Acute nephrotic syndrome – kidney damage.
- Hemorrhagic glomerulonephritis – inflammation of the renal corpuscles.
- Priapism – erection lasting > 4 h without sexual stimulation; 95% of cases ischemic or low-flow priapism (LFP), which is very painful; LFP can lead to irreversible erectile dysfunction after only 4 h; therapy: blood aspiration and possibly intracavernosal (i.c.) sympathomimetic injection; “high-flow” priapism (HFP) does not require immediate intervention
