Definition and properties When we take a tablet or capsule, it contains a defined amount of an active pharmaceutical ingredient. Usually, the full dose does not enter the bloodstream. Some active ingredients are not fully released from the dosage form (liberation), others are only partially absorbed from the intestine (absorption), and some are metabolized in … Bioavailability
New drugs are protected Newly introduced drugs are usually protected by patent. Another company is not allowed to copy these drugs and distribute them themselves without the manufacturer’s consent. However, this protection expires after a few years. For example, the antidepressant escitalopram (Cipralex) was approved in many countries in 2001 and the patent protection was … Generic
P-glycoprotein P-glycoprotein (P-gp, MDR1) is a primary active efflux transporter with a molecular weight of 170 kDa, belonging to the ABC superfamily and consisting of 1280 amino acids. P-gp is the product of the -gene (formerly: ). P is for , ABC is for . Occurrence P-glycoprotein is found on various tissues of the human … P-Glycoprotein
