Products Enalapril is commercially available in tablet form (Reniten, generics). It has been approved in many countries since 1984. The active ingredient is also combined fixed with hydrochlorothiazide. Structure and properties Enalapril (C20H28N2O5, 376.45 g/mol) is present in drugs as enalapril maleate, a white powder that is sparingly soluble in water. Enalapril is the prodrug … Enalapril: Drug Effects, Side Effects, Dosage and Uses
Products Perindopril is commercially available in the form of film-coated tablets and has been approved in many countries since 1989 (Coversum N, generic). It is also approved as a fixed combination with indapamide (Coversum N combi, generic) or amlodipine (Coveram, generic). Generic of the fixed combination with amlodipine was first registered in many countries in … Perindopril
Effects The RAAS is activated in the presence of low blood pressure, decreased blood volume, hyponatremia, and sympathetic activation. Main actions: mediated via angiotensin II: Vasoconstriction Blood pressure increase Release of catecholamines Hypertrophy at the heart Mediated via aldosterone: Water and sodium ions are retained Potassium ions and protons are eliminated Overview of the RAAS … Renin-Angiotensin-Aldosterone System (RAAS)
Products Telmisartan is commercially available in tablet form (Micardis, Micardis Plus + hydrochlorothiazide, generics). It has been approved in many countries since 1998. Generics entered the market in December 2013. In 2010, a fixed combination with amlodipine was registered (Micardis Amlo). Kinzal is no longer marketed in many countries. Structure and properties Telmisartan (C33H30N4O2, Mr … Telmisartan
Products Cilazapril is commercially available in the form of film-coated tablets (Inhibace). Fixed combinations with hydrochlorothiazide are available (Inhibace plus). Cilazapril has been approved in many countries since 1990. Structure and properties Cilazapril (C22H31N3O5, Mr = 417.5 g/mol) exists as a white crystalline powder that is sparingly soluble in water. It is a prodrug that … Cilazapril
Products Eprosartan is commercially available in the form of film-coated tablets (Teveten, generics). It has been approved in many countries since 1999 and is also used in fixed combination with hydrochlorothiazide (Teveten plus, generic). Structure and properties Eprosartan (C23H24N2O4S, Mr = 424.5 g/mol) is present in drugs as eprosartan mesilate, a white crystalline powder that … Eprosartan
Products Candesartan is commercially available in tablet form (Atacand, Blopress, generics). It is also combined fixed with hydrochlorothiazide (Atacand plus, Blopress plus, generics). Candesartan has been approved in many countries since 1997. In 2020, a fixed combination with amlodipine was also released. Structure and Properties Candesartan (C24H20N6O3, Mr = 440.45 g/mol) is administered in the … Candesartan
Products Losartan is commercially available in the form of film-coated tablets (Cosaar, generics). It has been approved in many countries since 1994 and was the first agent in the sartan group. Losartan is also combined with the diuretic hydrochlorothiazide (Cosaar Plus, generic). Structure and properties Losartan (C22H23ClN6O, Mr = 422.9 g/mol) is a biphenyl, imidazole, … Losartan
Products Irbesartan is commercially available in the form of film-coated tablets as a monopreparation (Aprovel, generic) and as a fixed combination with hydrochlorothiazide (Co-Aprovel). It has been approved in many countries since 1997. Generics entered the market in many countries in August 2012. Generic versions of the combination preprinted with hydrochlorothiazide went on sale in … Irbesartan
Vascular tone corresponds to the general state of tension of the vascular musculature, which is responsible for blood flow. Higher regulation is the responsibility of the sympathetic nervous system, but local regulators are also available to the organism. Abnormal contractions of the vascular musculature are called vasospasms and can occur in the context of various … Vascular Tone: Function, Role & Diseases
Products Benazepril was commercially available as film-coated tablets (Cibacen, off label). It was also available as a fixed-dose combination with hydrochlorothiazide (Cibadrex, off label). Benazepril was approved in many countries beginning in 1990. Structure and properties Benazepril (C24H28N2O5, Mr = 424.5 g/mol) is present in drugs as benazepril hydrochloride, a white crystalline powder that is … Benazepril
Introduction CoAprovel® is an antihypertensive drug containing 2 active ingredients: hydrochlorothiazide and irbesartan. It is used when one of these active ingredients does not lower blood pressure sufficiently, either due to lack of potency or due to side effects that are too strong at low doses. As these 2 substances intervene in different ways in … CoAprovel
