Products
Eprosartan is commercially available in the form of film-coated tablets (Teveten, generics). It has been approved in many countries since 1999 and is also used in fixed combination with hydrochlorothiazide (Teveten plus, generic).
Structure and properties
Eprosartan (C23H24N2O4S, Mr = 424.5 g/mol) is present in drugs as eprosartan mesilate, a white crystalline powder that is insoluble in water. It is an imidazole and thiophene derivative. Unlike other sartans, eprosartan does not contain a biphenyl or a tetrazole.
Effects
Eprosartan (ATC C09CA02) has antihypertensive properties by abolishing the physiologic effects of angiotensin II. Angiotensin II is a peptide hormone directly involved in the development of hypertension. It has a potent vasoconstrictor effect and increases aldosterone release, which in turn causes increased water and sodium retention. The effects of eprosartan are due to selective blockade of AT1 receptor. Eprosartan has additional sympatholytic properties.
Indications
For the treatment of hypertension (essential hypertension).
Dosage
According to the SmPC. Tablets are taken once a day at the same time of day, regardless of meals.
Contraindications
- Hypersensitivity
- Pregnancy
- Severe kidney disease
- Combination with aliskiren in patients with diabetes mellitus or impaired renal function.
For complete precautions, see the drug label.
Interactions
Other antihypertensive agents may cause increased blood pressure lowering. Other interactions are possible with ACE inhibitors and lithium.
Adverse effects
The most common possible adverse effects include indigestion, headache, dizziness, fatigue, depression, chest pain, palpitations, urinary tract infections, upper respiratory tract disorders, muscle and joint pain, edema weakness, injury, and pain.
