What is antithrombin? Antithrombin is a protein produced in the liver and is also called antithrombin III or antithrombin 3 (AT III for short). It plays an important role in hemostasis. While it has little effect on primary hemostasis, it can effectively inhibit secondary hemostasis (blood clotting): Antithrombin ensures the degradation of thrombin (Factor IIa) … Antithrombin – what the laboratory value means
Introduction Mono-Embolex® is a so-called anticoagulant, i.e. a drug that inhibits blood coagulation (anticoagulant) and is thus used primarily for the prophylaxis and therapy of venous thrombosis and pulmonary embolism. The active ingredient of the preparation Mono-Embolex® is certoparin sodium. The active ingredient Certoparin belongs to the class of low molecular weight (=fractionated) heparins. These … Mono-Embolex
Fields of application Low molecular weight heparins such as the active ingredient certoparin in Mono-Embolex® are suitable for thrombosis prophylaxis and thrombosis therapy. Thrombosis is a disease that occurs in the blood vessels. A blood clot is formed via the coagulation cascade, which closes the blood vessel. Often thromboses are localized in the veins and … Fields of application | Mono-Embolex
Therapy monitoring In contrast to a standard heparin, the fluctuations of the drug level in the body are significantly lower with low-molecular-weight heparin. For this reason, therapy monitoring is usually not absolutely necessary. Exceptions are patients who have an increased risk of bleeding and/or patients who suffer from renal insufficiency. In such cases, the determination … Therapy monitoring | Mono-Embolex
Pregnancy and lactation There is a lot of experience regarding the use of low molecular weight heparins in pregnancy. In the first 12 weeks of pregnancy, no harmful effect on the embryo could be observed when using Mono-Embolex®. This finding is based on approximately 2,800 observed pregnancies under Certoparin therapy. Mono-Embolex® does not appear to … Pregnancy and lactation | Mono-Embolex
Synonyms in a broader sense Phenprocoumon (active ingredient name) Coumarins Vitamin K antagonists (inhibitors) Anticoagulants Anticoagulant Side effects of Marcumar Side effects (so-called UAW’s, adverse drug reactions) and interactions with other drugs Among the most common undesirable effects of coumarin therapy are lighter bleeding with haematoma. These are usually harmless (2-5% of patients), so discontinuing … Side effects of Marcumar
When must Marcumar® not be given? In general, coumarins must not be administered during pregnancy, as they can cause severe damage both in the early stages of child development (“embryopathies”, third to eighth week of pregnancy) and in the later, usually less sensitive developmental stages (“fetopathies”, from the ninth week of pregnancy onwards). Alternatives to … When must Marcumar® not be given? | Side effects of Marcumar
