Products Betrixaban was approved in the United States in 2017 in capsule form (Bevyxxa). The drug has not yet been approved in the EU (Dexxience). Structure and properties Betrixaban (C23H22ClN5O3, Mr = 451.9 g/mol) is present in the drug as betrixaban maleate. It is a pyridine and anthranilamide derivative. Effects Betrixaban has antithrombotic properties. The … Betrixaban
Products In many countries, no drugs containing warfarin are approved, and the closely related phenprocoumon (Marcoumar) is mainly used. However, warfarin is commonly used in other countries, particularly the United States, and is commercially available in tablet form (Coumadin) and other forms. It was approved in the United States in 1954. Structure and properties Warfarin … Warfarin
Products Acetylsalicylic acid is commercially available in the low dosage of 100 mg in the form of enteric-coated film-coated tablets (Aspirin Cardio, generics; in Germany and Austria, Aspirin Protect). The drug has been approved in many countries since 1992. Aspirin Cardio 300 mg is also used. In the United States, drugs with 81 mg (= … Acetylsalicylic Acid 100 mg
Products Oils for medicinal use and medicines and dietary supplements made from them are available in pharmacies and drugstores. Fatty oils are also available in grocery stores. Structure and properties Fatty oils belong to the lipids. They are lipophilic and viscous liquids composed mainly of triglycerides. These are organic compounds of glycerol (glycerol) whose three … Fats Oils
Products Acenocoumarol is commercially available in tablet form (Sintrom, Sintrom mitis). It has been approved in many countries since 1955. Structure and properties Acenocoumarol (C19H15NO6, Mr = 353.3 g/mol) is a 4-hydroxycoumarin derivative. It is present in the drug as a racemate. Effects Acenocoumarol (ATC B01AA07) has anticoagulant and antithrombotic properties. The effects are due … Acenocoumarol
Symptoms Deep vein thrombosis develops as a result of a blood clot in the deep veins. Typical symptoms are: Painful and swollen legs and calves, edema. Redness and discoloration of the skin Locally increased temperature Often asymptomatic It poses a significant risk for the development of pulmonary embolism when part of the thrombus breaks loose … Air Travel Thrombosis
Products Phenprocoumon is commercially available in tablet form (Marcoumar). It has been approved in many countries since 1953. Warfarin (Coumadin) is more common in some countries. Structure and properties Phenprocoumon (C18H16O3, Mr = 280.32 g/mol) is a derivative of 4-hydroxycoumarin and a racemate. The -enantiomer is pharmacologically more active. Phenprocoumon exists as a fine, white, … Phenprocoumon
Symptoms Possible symptoms of pulmonary embolism include: Shortness of breath (dyspnea), rapid breathing, cyanosis. Chest pain Cough with blood or sputum Rapid heartbeat Fever, sweating Loss of consciousness (syncope) Low blood pressure, shock Symptoms of deep vein thrombosis, such as a swollen, warm leg The severity varies and depends, among other things, on how large … Pulmonary Embolism Causes and Treatment
Products Tenecteplase is commercially available as an injectable (metalysis). The drug has been approved in many countries since 2000. Structure and properties Tenecteplase is a recombinant fibrin-specific plasminogen activator produced by biotechnological methods. The glycoprotein consists of 527 amino acids. The sequence is modified from native tissue-specific plasminogen activator (t-PA) at three sites. Effects Tenecteplase … Tenecteplase
P-glycoprotein P-glycoprotein (P-gp, MDR1) is a primary active efflux transporter with a molecular weight of 170 kDa, belonging to the ABC superfamily and consisting of 1280 amino acids. P-gp is the product of the -gene (formerly: ). P is for , ABC is for . Occurrence P-glycoprotein is found on various tissues of the human … P-Glycoprotein
