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Graft-versus-host reaction is an immunologic complication that can lead to graft rejection in allogeneic transplantation. Meanwhile, the reaction can be controlled by the prophylactic administration of immunosuppressants. Nevertheless, a mortality rate of ten percent still applies today. What is the graft-versus-host reaction? In a transplant, organic material is transplanted from a donor into a recipient. … Graft-versus-host Reaction: Causes, Symptoms & Treatment