Products Phenformin has been off the market in many countries since the late 1970s because of the potential adverse effects. Structure and properties Phenformin (C10H15N5, Mr = 205.3 g/mol) is a biguanide with a similar structure to metformin. Phenformin was the first agent in this group of drugs. Effects Phenformin (ATC A10BA01) has antidiabetic and … Phenformin
Products Ertugliflozin was approved in the United States in 2017 and in the EU and many countries in 2018 in film-coated tablet form (Steglatro). The agent is also combined fixed with sitagliptin (Steglujan) and with metformin (Segluromet). Structure and properties Ertugliflozin (C22H25ClO7, Mr = 436.9 g/mol) is present in the drug as ertugliflozin-L-pyroglutamic acid, a … Ertugliflozin
Products Semaglutide was approved in the US and EU in 2017 and in many countries in 2018 as a solution for injection (Ozempic). The agent is structurally and pharmacologically related to liraglutide (Victoza), which, unlike semaglutide, is injected once daily (both Novo Nordisk). In 2019, tablets containing semaglutide were approved for the first time in … Semaglutide
Products The fixed combination Xultophy was approved in many countries and in the EU in 2014 as an injection solution in a prefilled pen. It was released in the United States in 2016. Structure and properties IDegLira is the name given to the combination of the insulin insulin degludec (IDeg, Tresiba) with the GLP-1 receptor … IDegLira
Products In 2012, dapagliflozin (Forxiga) was approved in the EU as the first agent in the new group of SGLT2 inhibitors. Several drugs are now on the market worldwide (see below). Structure and properties The SGLT2 inhibitors are derived from phlorizin, a -glucoside and natural substance first isolated from apple tree bark in 1835. Phlorizin … SGLT2 Inhibitor
Products Buformin (Silubin retard, dragées) is no longer commercially available in many countries and many more because of the potential adverse effects. Structure and properties Buformin (C6H15N5, Mr = 157.2 g/mol) is a 1-butylbiguanide with a similar structure to metformin from the same drug group. It is present in drugs as buformin hydrochloride. Effects Buformin … Buformin
