Bromocriptine: Effects, Uses, Side Effects

How Bromocriptine Works Bromocriptine is chemically an ergot alkaloid. The active ingredient binds to binding sites (receptors) of the nerve messenger dopamine and activates them, thereby inhibiting the release of prolactin from the anterior pituitary. The activation of dopamine receptors is also used to treat Parkinson’s disease and acromegaly (increased growth of certain body parts). … Bromocriptine: Effects, Uses, Side Effects

Erythromelalgia: Causes, Symptoms & Treatment

Erythromelalgia is a rare circulatory disorder that is associated with seizure-like recurring painful swelling in the legs, feet, arms, and/or hands. Men and women can be equally affected by erythromelalgia. What is erythromelalgia? Erythromelalgia is the name given to a rare neuro-vascular disorder and functional circulatory disorder associated with seizure-like painful hyperemia (increased blood flow) … Erythromelalgia: Causes, Symptoms & Treatment

Antiparkinsonian

Effects The majority of antiparkinsonian drugs are directly or indirectly dopaminergic. Some are anticholinergic in action. Indications Parkinson’s disease, including drug-induced Parkinson’s disease in some cases. Drug treatment Overview of drug therapy: 1. dopaminergic agents Levodopa is a precursor of dopamine and is considered the most important and effective pharmacotherapy for PD. Combining it with … Antiparkinsonian

Acromegaly: Too Much Growth Hormone

Definition Acromegaly refers to a pathological change in growth due to chronic somatotropin excess. The condition occurs primarily in individuals aged 40-50 years. If acromegaly is not adequately treated, life expectancy is shortened by approximately 10 years due to secondary diseases. Symptoms The symptoms of acromegaly initially remain inconspicuous. The symptoms are nonspecific and develop … Acromegaly: Too Much Growth Hormone

Bromocriptine

Products Bromocriptine is commercially available in tablet form (Parlodel). It was developed at Sandoz in the 1960s and has been approved in many countries since 1975. Generic versions are now available in many countries. Structure and properties Bromocriptine (C32H40BrN5O5, Mr = 654.6 g/mol) is a brominated derivative of the natural ergot alkaloid ergocryptine. It is … Bromocriptine

Bromocriptine: Effects, Uses & Risks

Bromocriptine is an active substance that belongs to the group of ergot alkaloids. The active ingredient is used primarily if there is a disease that is due to too high a level of prolactin in the blood. What is bromocriptine? Because of its special properties, bromocriptine is used to treat health problems and diseases that … Bromocriptine: Effects, Uses & Risks

Triflupromazine: Effects, Uses & Risks

Triflupromazine belongs to the class of neuroleptics. As such, the drug is used to treat psychiatric disorders. In addition, however, it can also be used in other medical specialties. In the Federal Republic of Germany, triflupromazine may no longer be used or prescribed since 2003 due to changes in drug law, as there is no … Triflupromazine: Effects, Uses & Risks

Dopamine Agonists

Products Dopamine agonists are commercially available in the form of tablets, sustained-release tablets, transdermal patches, and injectables, among others. Structure and properties The first active ingredients, such as bromocriptine (Figure), were derived from ergot alkaloids. These are referred to as ergoline dopamine agonists. Later, agents with a nonergoline structure, such as pramipexole, were also developed. … Dopamine Agonists

Prolactinomas

Symptoms Symptoms depend on sex, age, adenoma size, and prolactin levels. In women, prolactinoma manifests as menstrual irregularities (absence or delay of periods), infertility, and lactation. In men, it results in testosterone deficiency, reduced libido, erectile dysfunction, impotence, decreased beard growth, and rarely breast pain and lactation. In children, puberty is additionally delayed. In a … Prolactinomas

Alkaloids: Function & Diseases

Alkaloids are organic compounds that can affect animal and human organisms. Most alkaloids are produced by plants. What are alkaloids? The term alkaloids comes from Arabic and means plant ash. Alkaloids are naturally occurring organic compounds produced in the secondary metabolism of plants, bacteria, and fungi. These secondary metabolites, unlike the primary metabolites, are not … Alkaloids: Function & Diseases

Pipamperon

Products Pipamperone is commercially available in tablet form (dipiperone). It has been approved in many countries since 1964. Structure and properties Pipamperone (C21H30FN3O2, Mr = 375.5 g/mol) is present in drugs as pipamperondihydrochloride. It is structurally closely related to haloperidol, which also belongs to the butyrphenones. Butyrphenones, like numerous other active ingredients, originated in the … Pipamperon

Ropinirole: Effects, Uses & Risks

The drug ropinirole belongs to the dopamine agonists. It is used to treat Parkinson’s disease and restless legs syndrome. What is ropinirole? The drug ropinirole belongs to the group of dopamine agonists. It is used to treat Parkinson’s disease and restless legs syndrome. Ropinirole is a medicinal substance that belongs to the group of dopamine … Ropinirole: Effects, Uses & Risks