Products Zuclopenthixol is commercially available in the form of dragées, as drops, and as a solution for injection (Clopixol). It has been approved in many countries since 1977. Structure and properties Zuclopenthixol (C22H25ClN2OS, Mr = 400.7 g/mol) is present in drugs as zuclopenthixol dihydrochloride, zuclopenthixol acetate, or zuclopenthixol decanoate. Zuclopenthixol decanoate is a yellow, viscous, … Zuclopenthixol
Products Ziprasidone is commercially available in capsule form (Zeldox, Geodon, generics) and other forms. It has not yet been registered in many countries. It was first approved in the United States in 2001. Structure and properties Ziprasidone (C21H21ClN4OS, Mr = 412.9 g/mol) is present in the capsules as ziprasidone hydrochloride monohydrate, a white to light … Ziprasidone
Products Risperidone is commercially available as film-coated tablets, meltable tablets, an oral solution, and a suspension for intramuscular administration (Risperdal, generics). The active ingredient has been approved in many countries since 1994. Structure and properties Risperidone (C23H27FN4O2, Mr = 410.5 g/mol) exists as a white powder that is practically insoluble in water. It is a … Risperidone: Drug Effects, Side Effects, Dosage and Uses
Products Quetiapine is commercially available in the form of film-coated tablets and sustained-release tablets (Seroquel / XR, generic, auto-generic). It has been approved in many countries since 1999. Generics of film-coated tablets entered the market in 2012, and generics of sustained-release tablets were first registered in 2013. Structure and properties Quetiapine (C21H25N3O2S, Mr = 383.5 … Quetiapine
Products Sulpiride is commercially available in the form of capsules and tablets (Dogmatil). It has been approved in many countries since 1976. Structure and properties Sulpiride (C15H23N3O4S, Mr = 341.4 g/mol) is a racemate. It exists as a white crystalline powder that is practically insoluble in water. It belongs to the substituted benzamides. Effects Sulpiride … Sulpiride (Dogmatil): Drug Effects, Side Effects, Dosage and Uses
Products Cariprazine was approved in the United States in 2015 and in many countries and the EU in 2018 in capsule form (Reagila, some countries: Vraylar). Structure and properties Cariprazine (C21H32Cl2N4O, Mr = 427.4 g/mol) is a piperazine and dimethylurea derivative. It is present in the drug as cariprazine hydrochloride, a white powder. Active metabolites … Cariprazine
Products Thiethylperazine was commercially available in the form of dragées, as a solution for injection, and as suppositories (Torecan, Novartis). It had been approved in many countries since 1960. The suppositories went out of circulation in 2010 due to lack of demand. The other dosage forms were withdrawn from the market in 2014. Structure and … Thiethylperazine
Products Thioridazine has been off the market in many countries since 2005 because of cardiac risks. Melleril and Mellerette tablets are out of commerce. In Germany and other countries, thioridazine remains on the market. Structure and properties Thioridazine (C21H26N2S2, Mr = 370.6 g/mol) is a phenothiazine derivative with a piperidinyl alkyl side chain. In drugs, … Thioridazine
Products Promazine is commercially available in the form of dragées (Prazine). It has been approved in many countries since 1957. Structure and properties Promazine (C17H20N2S, Mr = 284.4 g/mol) is present in drugs as promazine hydrochloride, a white crystalline powder that is very soluble in water. It is a dimethylamine derivative of phenothiazine and structurally … Promazine
Products Clozapine is commercially available in tablet form (Leponex, generic). It has been approved in many countries since 1972. It is also known as Clozaril in some countries. Clozapine was developed at Wander and Sandoz. Structure and properties Clozapine (C18H19ClN4, Mr = 326.8 g/mol) exists as a yellow crystalline powder that is practically insoluble in … Clozapine
Products Clotiapine is commercially available in tablet form (Entumin). It has been approved in many countries since 1967. Structure and properties Clotiapine (C18H18ClN3S, Mr = 343.87 g/mol) is a dibenzothiazepine. The structurally closely related neuroleptic quetiapine (Seroquel) also belongs to this group of drugs. Effects Clotiapine (ATC N05AH06) has adrenolytic, antidopaminergic, anticholinergic, antihistamine, sedative, psychomotor … Clotiapine
Products Penfluridol is no longer available as a drug in many countries. Semap tablets are out of commerce. Structure and properties Penfluridol (C28H27ClF5NO, Mr = 523.96 g/mol) is a diphenylbutylpiperidine. Effects Penfluridol (ATC N05AG03) is potent antidopaminergic, antiemetic, and potent antipsychotic against hallucinations and delusions. It has minimal activity at the 5-HT2 receptor (antiserotonergic) and … Penfluridol
