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Symptoms In cystic fibrosis (CF, cystic fibrosis), different organ systems are affected, resulting in a heterogeneous clinical picture with symptoms of varying severity: Lower respiratory tract: Chronic cough with viscous mucus formation, obstruction, recurrent infectious diseases, e.g., with , inflammation, remodeling of the lungs (fibrosis), pneumothorax, respiratory insufficiency, shortness of breath, wheezing, oxygen deficiency. Upper … Cystic Fibrosis: Causes and Treatment