Products Azacitidine is commercially available as a lyophilizate for the preparation of a suspension for injection (Vidaza, generic). It has been approved in many countries since 2006. Structure and properties Azacitidine (C8H12N4O5, Mr = 244.2 g/mol) is a derivative of the nucleoside cytidine found in nucleic acids. It belongs to the pyrimidine nucleoside analogues. Azacitidine … Azacitidine
Zalcitabine is a so-called antiviral drug for oral administration. It is classified as a member of the nucleoside reverse transcriptase inhibitor (NRTI) group of drugs and is used in the antiviral therapy of HIV infection. What is zalcitabine? Zalcitabine belongs to the NRTI group of drugs, which are antiretroviral agents. It was first produced by … Zalcitabine: Effects, Uses & Risks
Uridine is described as a nucleoside according to biochemical or pharmacological criteria. Consequently, it is an organic molecule consisting of a nucleobase (building block of DNA) and pentoses (carbon-rich monosaccharides). Uridine is used in combination with the active ingredient cytidine to provide supportive treatment for inflammation of the nerves and diseases of the muscles (myopathies). … Uridine: Effects, Uses & Risks
Cytidine belongs to the nucleosides and is composed of the nucleic base cytosine and the sugar ribose. It forms a base pair with guanosine via hydrogen bonding. It also plays a central role in pyrimidine metabolism. What is cytidine? Cytidine represents a nucleoside composed of cytosine and ribose. The nitrogen base cytosine is involved in … Cytidine: Function & Diseases
Alkylation characterizes the transfer of an alkyl group from one molecule to another. Alkylations have mutagenic and carcinogenic effects, as DNA and RNA are often attacked and altered by alkylating agents. The so-called alkylating agents are used in medicine, on the one hand, to inhibit cell growth as cytostatics and, on the other hand, are … Alkylation: Function, Tasks, Role & Diseases
Emtricitabine is a medical agent that belongs to the group of chemical analogues. Emtricitabine belongs to the nucleosides, more precisely to the substance cytidine. Emtricitabine exerts a virostatic effect in the human organism and for this reason is used, among other things, to treat HIV, both for people with HIV-1 and HIV-2. What is emtricitabine? … Emtricitabine: Effects, Uses & Risks
The active substance lamivudine is used to treat the immunodeficiency disease AIDS and hepatitis B infections. It belongs to the antiviral drug group. What is HIV infection? Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) that forms a chemical analog of cytidine, which is one of the nucleosides. The drug is used to treat HIV-1 … Lamivudine: Effects, Uses & Risks
A nucleoside always consists of a nucleic base linked to the monosaccharide ribose or deoxyribose by an N-glycosidic bond. All 5 nucleic bases – the building blocks of DNA and RNA double and single helices – can be enzymatically converted into nucleosides. Some glycosides have physiological significance such as adenosine, which is the basic building … Nucleosides: Function & Diseases
Guanosine is the nucleoside of the purine base guanine and is formed by the addition of the simple sugar ribose. If deoxyribose, rather than ribose, is attached, it is deoxyguanosine. Guanosine is a component of the helices and double helices of RNA. The analogue deoxyguanosine is part of DNA. Guanosine, as a guanosine triphosphate (GTP) … Guanosine: Function & Diseases
Transfer RNA is a short-chain RNA composed of 70 to 95 nucleic bases and has a cloverleaf-like structure with 3 to 4 loops in the two-dimensional view. For each of the 20 known proteinogenic amino acids, there exists at least 1 transfer RNA that can take up “its” amino acid from the cytosol and make … Transfer RNA: Function & Diseases
