Products Abemaciclib was approved in the form of film-coated tablets in the United States in 2017, in the EU in 2018, and in many countries in 2019 (Verzenios). Structure and properties Abemaciclib (C27H32F2N8, Mr = 506.6 g/mol) exists as a white to yellow powder. Effects Abemaciclib (ATC L01XE50) has antitumor and antiproliferative properties. The effects … Abemaciclib
Products Olaparib was approved in the United States and EU in 2014 and in many countries in 2015 in capsule form (Lynparza). Later, film-coated tablets were also registered. Structure and properties Olaparib (C24H23FN4O3, Mr = 434.5 g/mol) Effects Olaparib (ATC L01XX46) has antitumor and cytotoxic properties. The effects are due to inhibition of PARP (poly-(ADP-ribose) … Olaparib
Products Vandetanib is commercially available in the form of film-coated tablets (Caprelsa). It was approved in the EU in 2011. It was registered in many countries in May 2012. Structure and properties Vandetanib (C22H24BrFN4O2, Mr = 475.4 g/mol) is a quinazolinamine and piperidine derivative that is practically insoluble in water. Effects Vandetanib (ATC L01XE12) is … Vandetanib
Products Duloxetine is commercially available in the form of capsules (Cymbalta, generic). It has been approved in many countries since 2005. Structure and properties Duloxetine (C18H19NOS, Mr = 297.4 g/mol) is present in drugs as pure -duloxetine hydrochloride, a white to light brown powder that is sparingly soluble in water. Effects Duloxetine (ATC N06AX21) has … Duloxetine
Products Bezafibrate is commercially available in the form of sustained-release tablets (Cedur retard). It has been approved in many countries since 1979. Structure and properties Bezafibrate (C19H20ClNO4, Mr = 361.8 g/mol) lies as a white crystalline powder that is practically insoluble in water. Effects Bezafibrate (ATC C10AB02) primarily lowers elevated blood triglyceride levels. It has … Bezafibrate
