Products Most statins are commercially available in the form of film-coated tablets, and some are also available as capsules. The first active ingredient to be marketed was lovastatin from Merck in the United States in 1987. In many countries, simvastatin (Zocor) and, shortly thereafter, pravastatin (Selipran) were the first agents to be approved in 1990. … Statins
Products Evolocumab was approved in the EU and US in 2015 and in many countries in 2016 in the form of a solution for injection (Repatha). Structure and properties Evolocumab is a human IgG2 monoclonal antibody with a molecular mass of 141.8 kDa. It is produced by biotechnological methods. Effects Evolocumab (ATC C10AX13) has lipid-lowering … Evolocumab
Products Ezetimibe is commercially available in tablet form, as a monopreparation (Ezetrol, generic), and as a fixed combination with simvastatin (Inegy, generic) and with atorvastatin (Atozet). Also released is a combination with rosuvastatin. Ezetimibe was approved in many countries and in the United States in 2002. Generic and auto-generics entered the market in November 2017. … Ezetimibe
Products Colestipol is commercially available as granules (Colestid). It has been approved in many countries since 1978. Structure and properties Colestipol is present in drugs as colestipol hydrochloride. It is a basic, high-molecular-weight anion-exchange resin. Effects Colestipol (ATC C10AC02) has lipid-lowering (LDL) properties by binding bile acids in the intestine and delivering them to excretion. … Colestipol
Products Colestyramine is commercially available as a powder in sachets (Quantalan). It has been approved in many countries since 1990. Structure and properties Colestyramine is a strongly basic anion exchange resin in the chloride form, consisting of a styrene-divinylbenzene copolymer with quaternary ammonium groups. It exists as a white, fine, hygroscopic powder that is insoluble … Colestyramine: Drug Effects, Side Effects, Dosage and Uses
Products Pravastatin is commercially available in tablet form (Selipran, generics). It has been approved in many countries since 1990. Structure and properties Pravastatin (C23H36O7, Mr = 424.5 g/mol) is present in drugs as pravastatin sodium, a white to yellowish-white powder or crystalline powder that is readily soluble in water. It is not a prodrug, unlike … Pravastatin
Products Gemfibrozil is commercially available in the form of film-coated tablets (Gevilon, Gevilon Uno). It has been approved in many countries since 1985. Structure and properties Gemfibrozil (C15H22O3, Mr = 250.3 g/mol) exists as a white powder that is practically insoluble in water. Effects Gemfibrozil (ATC C10AB04) has lipid-lowering properties. It lowers VLDL, triglycerides, total … Gemfibrozil
Effects Fibrates (ATC C10AB) have lipid-lowering properties. They primarily lower elevated blood triglyceride levels and have a moderate effect on LDL cholesterol and slightly increase HDL. The effects are due to activation of nuclear receptors PPAR (mainly PPARα). Indications Blood lipid disorders, especially hypertriglyceridemia. Agents Bezafibrate (Cedur retard) Fenofibrate (Lipanthyl) Fenofibric acid (Trilipix) Gemfibrozil (Gevilon) … Fibrate
Products Nicotinic acid was commercially available in the form of modified-release tablets as a fixed combination with laropiprant (Tredaptive, 1000 mg/20 mg). The combination was approved in many countries in 2009, replacing earlier monopreparations such as Niaspan. The drug was withdrawn from the market on January 31, 2013. Structure and properties Nicotinic acid (C5H5NO2, Mr … Nicotinic Acid
Products Fenofibrate is commercially available in the form of capsules (lipanthyl). It has been approved in many countries since 1977. In 2014, a fixed combination with simvastatin was registered (Cholib); see Fenofibrate Simvastatin. Structure and properties Fenofibrate (C20H21ClO4, Mr = 360.8 g/mol) exists as a white crystalline powder that is practically insoluble in water. It … Fenofibrate
Products Fenofibric acid was approved in many countries in 2013 in sustained-release capsule form (Trilipix). The capsules are not commercially available. Structure and properties Fenofibric acid (C17H15ClO4, Mr = 318.8 g/mol) is present in the drug as the choline salt (choline fenofibrate), a white to yellow powder that is very soluble in water. Fenofibric acid … Fenofibric Acid
Indications Hyperlipidemia Agents Colestyramine (Quantalan) Colestipol (Colestid) Sodium polystyrene sulfonate (Resonium A) for the treatment of hyperkalemia. Resina polystyrenolica anionica fortis (Ipocol).
