Intestinal absorption After ingestion of a drug, the active ingredient must first be released. This process is called release (liberation), and it is a prerequisite for subsequent absorption. Absorption (formerly: resorption) is the passage of an active pharmaceutical ingredient from the digestive pulp into the bloodstream in the stomach and intestines. Absorption occurs primarily in … Absorption
Pharmacodynamics and pharmacokinetics. When we take a tablet, we are usually interested in its immediate effects. The drug is supposed to relieve a headache or reduce symptoms of a cold. At the same time, we may think about the possible side effects it may trigger. The desired and undesired effects that a drug exerts on … ADME
Definition and mechanisms A pharmacokinetic booster is an agent that improves the pharmacokinetic properties of another agent. It is a desirable drug interaction It can exert its effects at different levels (ADME): Absorption (uptake into the body). Distribution (distribution) Metabolism and first-pass metabolism (metabolization). Elimination (excretion) Pharmacokinetic enhancers can increase absorption, increase distribution to an … Pharmacokinetic Booster
Products Polysorbate 80 is present in many drugs as an excipient. These include tablets, injectables (e.g., amiodarone), biologics (therapeutic proteins, vaccines), and solutions. It is also used in personal care products and in foods. Structure and properties Polysorbate 80 is a mixture of partial esters of fatty acids, mainly oleic acid, with sorbitol and its … Polysorbate 80
Elimination at the kidney The kidneys, along with the liver, play a central role in the elimination of pharmaceutical agents. They can be filtered at the glomerulus of the nephron, actively secreted at the proximal tubule, and reabsorbed at various tubular segments. In renal insufficiency, these processes are impaired. This may result in a renally … Dose Adjustment in Renal Insufficiency
Definition When two or more drugs are combined, they may affect each other. This is especially true with regard to their pharmacokinetics (ADME) and effects and adverse effects (pharmacodynamics). This phenomenon is called interaction and drug-drug interaction. Interactions are usually undesirable because they can lead to, for example, loss of efficacy, side effects, poisoning, hospitalization, … Interactions
Definition and properties When active pharmaceutical ingredients enter the bloodstream, they often bind to proteins, especially albumin, to a greater or lesser extent. This phenomenon is called protein binding, and it is reversible: drug + protein ⇌ drug-protein complex Protein binding is important, first, because only the free portion distributes to tissues and induces a … Protein Binding
Definition Onset of action is the time at which the effect of a drug becomes observable or measurable. There is a delay between the administration of the drug (application) and the onset of action. We refer to this period of time as the latency period. It is in the range of minutes, hours, days, or … Onset of Action
Definition Distribution (distribution) is a pharmacokinetic process that begins immediately after absorption of the drug from the intestine. During this process, the drug enters the bloodstream and travels to organs, body fluids, and tissues. Distribution is necessary for the drug to reach its drug target at a sufficient concentration. For example, an antidepressant must be … Distribution
In anatomy, protraction corresponds to a forward movement of individual body structures. The opposite movement is retraction. The increased protraction of the chin, for example, can promote a herniated disc in the long term. What is protraction? In anatomy, protraction plays a role as a movement term, especially in connection with the scapula, for example. … Protraction: Effect, Uses & Risks
What are prodrugs? Not all active pharmaceutical ingredients are directly active. Some must first be converted to the active substance by an enzymatic or non-enzymatic conversion step in the body. These are the so-called . The term was introduced by Adrien Albert in 1958. It is estimated that up to 10% of all active ingredients … Prodrugs
Definition and examples When a drug is administered, for example, a tablet is swallowed or an injection is injected into a vein, the active pharmaceutical ingredients subsequently spread throughout the body. This process is called distribution. Active ingredients distribute throughout the bloodstream, into tissues, and are eliminated through metabolism and excretion. Mathematically, the volume of … Volume of Distribution
