Effects Integrase inhibitors have antiviral against HIV viruses. They inhibit the catalytic activity of HIV integrase, which is an HIV-encoded enzyme required for viral replication. Integrase inhibition prevents integration of the HIV genome into the host cell genome during the early phase of infection. Indications For the treatment of infection with the HIV virus (HIV). … Integrase Inhibitors
Products Baloxavirmarboxil was approved in film-coated tablet form in Japan and the United States in 2018 and in many countries in 2020 (Xofluza). Structure and properties Baloxavirmarboxil (C27H23F2N3O7S, Mr = 571.5 g/mol) is a prodrug of baloxavir (synonym: baloxaviric acid). It is converted to the active drug by hydrolysis. It is practically insoluble in water. … Baloxavirmarboxil
Products Dolutegravir was approved in the United States and EU in 2013 in film-coated tablet form (Tivicay). It was registered in many countries in 2014. A fixed-dose combination with dolutegravir, abacavir, and lamivudine is also available (Triumeq). In 2017, a combination product with rilpivirine was launched in the US (Juluca). It was approved in the … Dolutegravir
