Products Febuxostat is commercially available in the form of film-coated tablets (Adenuric). It was approved in many countries in 2016. It was registered in the EU in 2008 and in the US in 2009 (US: Uloric). Structure and properties Febuxostat (C16H16N2O3S, Mr = 316.4 g/mol), unlike allopurinol, does not have a purine structure. It is … Febuxostat
Products Lesinurad was approved in the US in 2015, in the EU in 2016, and in many countries in 2017 in film-coated tablet form (Zurampic). A fixed-dose combination with allopurinol was released in the US in 2017 (Duzallo), in the EU in 2018, and in many countries in 2019. Structure and properties Lesinurad (C17H14BrN3O2S, Mr … Lesinurad
Symptoms Gout is an inflammatory disease of the joints that manifests acutely in attacks of severe pain that worsens with pressure, touch, and movement. The joints are swollen with inflammation, and the skin is red and warm. Fever is observed. Gout often begins in the lower extremities and at the metatarsophalangeal joint (podagra). Urat crystals … Gout Causes and Treatment
Products Allopurinol is in the form of tablets trade (Zyloric, generic). It is approved in many countries since the year 1966. Allopurinol is also combined with the URAT1 inhibitor lesinurad. Structure and properties Allopurinol (C5H4N4O, Mr = 136.1 g/mol) exists as a white powder that is very sparingly soluble in water. It is a derivative … Allopurinol (Zyloprim)