fumarates

Multiple Sclerosis Causes and Treatment

Symptoms Possible symptoms of multiple sclerosis include: Weakness, numbness of the extremities. Visual disturbances, eye pain, optic neuritis. Paresthesias (eg, formication, tingling), pain, nerve pain. Tremor, coordination / balance disorders. Speech and swallowing disorders Dizziness, lightheadedness Fatigue Urinary incontinence, constipation Sexual function disorders, erectile dysfunction The disease is often relapsing and recurrent (relapsing-remitting multiple sclerosis), … Multiple Sclerosis Causes and Treatment

Dimethyl Fumarate

Products Dimethyl fumarate is commercially available in the form of capsules with enteric-coated microtablets (Tecfidera). It has been approved in many countries since 2014. Dimethyl fumarate is also approved for the treatment of psoriasis (Skilarence). This article is related to MS therapy. In 2019, a new prodrug of the active ingredient was approved; see diroximelfumarate … Dimethyl Fumarate

Psoriasis Causes and Treatment

Symptoms Psoriasis is a chronic inflammatory, benign, and noninfectious skin disease. It manifests as symmetrical (bilateral), sharply demarcated, bright red, dry, raised plaques covered by silvery scales. Typically affected areas are the elbows, knees, and scalp. Itching, a burning sensation and pain are other symptoms, and scratching further aggravates the condition. Psoriasis can also affect … Psoriasis Causes and Treatment

Fumaric Acid

Products Fumaric acid is used as an excipient in medicinal products. Active ingredients are also derived from it. Structure and properties Fumaric acid (C4H4O4, Mr = 116.1 g/mol) is a dicarboxylic acid. It exists as a white, crystalline and odorless powder or as crystals and is sparingly soluble in water. The pharmacopoeia defines it in … Fumaric Acid

Diroximelfumarate

Products Diroximelfumarate was approved in the United States in 2019 in the form of sustained-release capsules (Vumerity). It should not be confused with dimethyl fumarate (Tecfidera). Structure and properties Diroximelfumarate (C11H13NO6, Mr = of 255.2 g/mol) exists as a white powder that is sparingly soluble in water. The active metabolite monomethyl fumarate (MMF, see below) … Diroximelfumarate