Products Amorolfine is commercially available for the treatment of a nail fungus as a nail polish (Loceryl, Curanel, 5%, generic). It has been approved in many countries since 1991. Curanel was released in April 2011 and, unlike Loceryl, is available without a doctor’s prescription. It is also sold as Curanail in other countries. In 2014, … Amorolfine
Products Antifungal products are commercially available as creams, ointments, powders, solutions, tablets, capsules, and injectables, among others. Structure and properties The antifungal agents are a structurally heterogeneous class of agents. However, several groups can be identified within the antifungals, such as the azole antifungals and the allylamines (see below). Effects Antifungals have antifungal, fungistatic, or … Antifungals
Products Azole antifungals are approved in many countries for both topical and systemic treatment. They are available in numerous dosage forms-including creams, an oral gel, powders, sprays, tablets, capsules, injectables, vaginal creams, and vaginal tablets. The first azole antifungal came on the market in the 1950s. Structure and properties The name azole refers to heterocycles … Azole Antifungals
Products Undecylenic acid is commercially available in many countries as an ointment (Undex, combination preparation). Solutions and creams are also available in some countries. Undecylenic acid has been used medicinally for many decades. Undex ointment has been approved in many countries since 1951. Structure and properties Undecylenic acid (C11H20O2, Mr = 184.3 g/mol) exists as … Undecylenic Acid
Products Echinocandins are commercially available as infusion preparations. Caspofungin was the first representative from this group to be approved in 2001, and in many countries in 2002. Structure and properties Echinocandins are semisynthetic agents derived from fermentation products of various fungi. These include , and F-11899 They are synthetic lipopeptides with a complex chemical structure … Echinocandine
Products Selenium disulfide is commercially available as a shampoo (suspension) in fixed combination with sulfur (ectoselen). It has been approved in many countries since 1952. Selsun has not been marketed since 2019. Structure and properties Selenium disulfide (SeS2, Mr = 143.1 g/mol) exists as a yellow-orange to reddish-brown powder that is practically insoluble in water. … Selenium Disulfide
Products Tolnaftate is commercially available as an ointment (Undex, combination). Quadriderm ointment is out of commerce. Structure and properties Tolnaftate (C19H17NOS, Mr = 307.4 g/mol) exists as a white to yellowish white powder that is practically insoluble in water. Effects Tolnaftate (ATC D01AE18) has fungistatic to fungicidal properties. Indications Fungal infections with susceptible pathogens.
Products Fluconazole is commercially available in capsule form, as a powder for suspension, and as an infusion solution (Diflucan, generic). It has been approved in many countries since 1989. Structure and properties Fluconazole (C13H12F2N6O, Mr = 306.3 g/mol) is a fluorinated triazole derivative. It exists as a white, crystalline and hygroscopic powder that is sparingly … Fluconazole
Products Flucytosine is commercially available as an infusion solution (Ancotil). Although it would also be available orally, in many countries only drugs for parenteral administration are available. Structure and properties Flucytosine (C4H4FN3O, Mr = 129.1 g/mol) is a nucleoside analog of the pyrimidine base cytosine. Effects Flucytosine (ATC D01AE21, ATC J02AX01) has antifungal (fungistatic) properties. … Flucytosine
Products Terbinafine cream has been approved in many countries since 1991 (Lamisil, generic). Structure and properties Terbinafine (C21H25N, Mr = 291.43 g/mol) is present in the drug as terbinafine hydrochloride, a white crystalline powder that is sparingly soluble in water. It belongs structurally to the allylamines. Effects Terbinafine (ATC D01AE15) has fungistatic to fungicidal properties … Terbinafine Cream
