Androgens: Steroid Hormones

Products Androgens are commercially available as oral tablets and capsules, transdermal gels and transdermal patches, and injectables, among others. Testosterone was first isolated in the 1930s. Structure and properties Androgens generally have a steroidal structure and are related to testosterone. They are steroid hormones that are often present as esters in drugs. Effects Androgens (ATC … Androgens: Steroid Hormones

Dienogest

Products Dienogest is commercially available in many countries as a fixed combination with estradiol valerate in tablet form (Qlaira). Furthermore, a monopreparation for endometriosis therapy is available (Visanne, see under Dienogest Endometriosis). The fixed combination with ethinyl estradiol (Valette, generic) was approved in many countries in 2014. Dienogest + estradiol Qlaira has been on the … Dienogest

Dienogest (Endometriosis Therapy)

Products Dienogest is commercially available for endometriosis therapy in tablet form (Visanne, generic). Structure and properties Dienogest (C20H25NO2, Mr = 311.4 g/mol) is a derivative of 19-nortestosterone (nandrolone) and carries a cyanomethyl group. Effects Dienogest (ATC G03DB08) has progestogenic and antiandrogenic properties. The effects are due to selective binding to progesterone receptors. Dienogest abolishes the … Dienogest (Endometriosis Therapy)

Doping in Competitive Sports

Products Doping agents include approved drugs, legal and illegal intoxicants, experimental agents, and illegally manufactured and trafficked substances. Doping includes non-drug doping methods, such as blood doping, in addition to drugs. Effects Doping agents differ in their pharmacological activities. Stimulants, for example, stimulate and thus increase alertness and aggressiveness for competition. In contrast, beta-blockers provide … Doping in Competitive Sports

Osteoporosis Causes and Treatment

Symptoms In osteoporosis, bones become weak, porous, and brittle and undergo structural changes. Even minor stresses can lead to a fracture, especially of the vertebrae, femoral neck, and wrists. Fractures pose a risk to the elderly and can lead to pain, hospitalization, surgery and disability. In the worst cases, they are even life-threatening. Other possible … Osteoporosis Causes and Treatment

Nandrolone

Products Nandrolone is commercially available as a solution for injection (Deca-Durabolin). It has been approved in many countries since 1960. Structure and properties Nandrolone (C18H26O2, Mr = 274.4 g/mol) is present in the drug in the form of the long-acting prodrug nandrolone decanoate, a white crystalline powder that is practically insoluble in water because of … Nandrolone