nateglinide

Diabetes Mellitus Type 2: Causes and Treatment

Symptoms The possible acute symptoms of type 2 diabetes include: Thirst (polydipsia) and hunger (polyphagia). Increased urination (polyuria). Visual disturbances Weight loss Fatigue, exhaustion, declining performance. Poor wound healing, infectious diseases. Skin lesions, itching Acute complications: Hyperacidity (ketoacidosis), hyperosmolar hyperglycemic syndrome. Untreated diabetes is far from harmless and can lead in the longer term to … Diabetes Mellitus Type 2: Causes and Treatment

Repaglinide

Products Repaglinide is commercially available in tablet form (NovoNorm, generic). It was approved in many countries in 1999. Structure and properties Repaglinide (C27H36N2O4, Mr = 452.6 g/mol) is a meglitinide and carbamoylmethylbenzoic acid derivative without sulfonylurea structure. It is a white, odorless powder that is practically insoluble in water due to its lipophilicity. In drugs, … Repaglinide

Glinides (Meglitinides): Diabetes Drugs

Products Glinides are commercially available in tablet form. Repaglinide (NovoNorm, USA: 1997) was the first to be approved in many countries in 1999, and nateglinide (Starlix) was approved a year later in 2000. Structure and properties The glinides differ structurally from the sulfonylureas. They are also referred to as meglitinide analogs. Repaglinide is a carbamoylmethylbenzoic … Glinides (Meglitinides): Diabetes Drugs

Nateglinide

Products Nateglinide is commercially available in the form of film-coated tablets (Starlix, Starlix mite). It has been approved in many countries since 2000. Structure and properties Nateglinide (C19H27NO3, Mr = 317.42 g/mol) is a cyclohexane derivative of the amino acid phenylalanine. It is a white powder that is practically insoluble in water. Effects Nateglinide (ATC … Nateglinide

Antidiabetics

Active ingredients Insulins substitute for endogenous insulin: Human insulin Insulin analogues Biguanides reduce hepatic glucose formation: Metformin (Glucophage, generic). Sulfonylureas promote insulin secretion from beta cells: Glibenclamide (Daonil, generic). Glibornuride (Glutril, off label). Gliclazide (Diamicron, generic). Glimepiride (Amaryl, generics) Glinides promote insulin secretion from beta cells: Repaglinide (NovoNorm, generic). Nateglinide (Starlix) Glitazones decrease peripheral insulin … Antidiabetics

Side effects | Glinide

Side effects As with other oral antidiabetics, gastrointestinal problems such as nausea and vomiting as well as diarrhea or constipation can occur during therapy with repaglinide (Novonorm®) or nateglinide (Starlix®). 10 percent of patients treated with glinides experienced headaches and diffuse visual disturbances, which were attributed to strongly fluctuating blood glucose levels. Under therapy with … Side effects | Glinide

Glinide

Synonyms in a broader sense Diabetes drugs, diabetes mellitus, repaglinide (e.g. Novonorm®) and nateglinide (e.g. Starlix®) How do the glinides repaglinide (e.g. Novonorm®) and nateglinide (e.g. Starlix®) work? Repaglinide (Novonorm®) and nateglinide (Starlix®) promote the release of insulin from the pancreas. A prerequisite for this is that the pancreas itself can still produce insulin. When … Glinide