Side effects
As with other oral antidiabetics, gastrointestinal problems such as nausea and vomiting as well as diarrhea or constipation can occur during therapy with repaglinide (Novonorm®) or nateglinide (Starlix®). 10 percent of patients treated with glinides experienced headaches and diffuse visual disturbances, which were attributed to strongly fluctuating blood glucose levels. Under therapy with repaglinide (Novonorm®) or nateglinide (Starlix®), liver values should be checked at least every six months, as the drugs can impair liver function.
Contraindications
Repaglinide (Novonorm®) or nateglinide (Starlix®) must not be taken if liver values are poor or if liver function is impaired. In the case of high blood sugar levels (over 300 mg/dl), therapy with repaglinide (Novonorm®) or nateglinide (Starlix®) is not indicated either. Other forms of therapy must be used here.
Interactions with other drugs
Drugs used to treat high blood pressure (ACE inhibitors: enalapril, verapamil, captopril, ramipril, lisinopril) increase the effect of glinides and can promote hypoglycemia, especially shortly after meals. Your doctor will take this into account and find out the appropriate dose for you. Other antihypertensive drugs from the group of beta-receptor blockers (atenolol, metoprolol, bisoprolol) and some drugs for depression (moclobemide) can also increase the effect of glinides and lead to hypoglycaemia.
Some painkillers taken in high doses, for example in the context of a rheumatic disease (acetylsalicylic acid over 3 grams per day), can also increase the effect of glinides. Medicines containing cortisone, which are given in the context of chronic rheumatic diseases as well as asthma and chronic bronchitis (COPD), can weaken the effect of glinides. The same applies to drugs that dilate the bronchial muscles (beta-mimetics: fenoterol, formoterol, salbutamol, salmeterol, terbutaline) and to diuretics prescribed for high blood pressure (hydrochlorothiazide, HCT, indapamide, xipamide). For these drugs, it is essential that you check your blood sugar regularly at the start of treatment with repaglinide (Novonorm®) or nateglinide (Starlix®) so that your doctor can adjust the dose if necessary.Other topics that might interest you: All information from the field of medicines can also be found under Medicines A-Z!
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