Bone consists of solid connective tissue (collagen), which is fibrously entangled. Limestone salts are ultimately deposited in this structure, which give the bone its final strength and mineralize it. In vitreous bone disease there is a gene mutation on chromosomes 7 and 17, which contain the information for the formation of the most important collagen … Brittle bone disease
Classification Brittle bone disease can be divided into different subtypes, each of which has its own characteristics. They often differ in the stature of the affected persons, as well as in the expression of symptoms and the course of the disease. Type I (type Lobstein): Type I of the brittle bone disease is the mildest … Classification | Brittle bone disease
Prophylaxis Since the brittle bone disease is genetically determined, it cannot be prevented by prophylactic measures. However, a lifestyle adapted to the disease can alleviate its course and symptoms. Those affected should not put additional strain on their bones, i.e. they should avoid alcohol and smoking. In addition, a balanced diet that avoids overweight and … Prophylaxis | Brittle bone disease
Synonyms in the broadest sense Brittle bone disease, congenital bone fragility, fragilitas osseum Definition Osteogenesis imperfecta (brittle bone disease) is a congenital disorder of the collagen balance. Collagen is a structure of the connective tissue. This makes the bones abnormally brittle. The gene mutation affects not only bones, but also tendons, ligaments, teeth and the … Osteogenesis imperfecta
Special feature The fractures are usually observed in the affected children until puberty. However, the greatest frequency of fractures seems to be in the first growth spurt at about 5 – 8 years of age. After puberty, the fractures stop. The disease can manifest itself differently in each affected person. Osteogenesis imperfecta (brittle bone disease) … Special feature | Osteogenesis imperfecta
Prophylaxis The actual disease cannot be avoided, only the bone fractures can be tried to prevent. Orthoses and splints can be used for this purpose. Orthoses are bone splints made of plastic in which, for example, the leg is embedded. The word probably originated from the words “orthopedic” and “prosthesis”. Orthoses are used for the … Prophylaxis | Osteogenesis imperfecta
