Important note: Paget’s disease is used synonymously for two different diseases. On the one hand, Paget’s disease is a disease from the field of gynecology and cancer. Paget’s disease from the field of gynecology is a malignant tumor (cancer) of the mammary duct in the area of the female nipple. Synonyms in a broader sense … Paget’s disease
Symptoms As already described above, a distinction is made between an asymptomatic and a symptomatic course of the disease. An asymptomatic course means that the disease was diagnosed as a so-called “random finding” and no main place of manifestation can be determined. Patients with a symptomatic course of the disease have pain, especially in the … Symptoms | Paget’s disease
General information An involvement of the skull bones is usually first noticed by a deformation or increase in size of the skull, since this becomes visible on the head quite early due to the lack of fat and connective tissue. Patients report, for example, that hats or helmets no longer fit them properly. X-ray If … General information | Paget’s disease
Bone biopsy It is relatively rare for a tissue sample of the bone (bone biopsy) to be taken. This diagnostic method is only necessary if, after CT and MRI examinations, bone metastases or Paget’s sarcoma are still suspected. The latter is a malignant bone tumor (osteosarcoma), which develops from degenerated osteoblasts in one percent of … Bone biopsy | Paget’s disease
Bisphosphonates for therapy The following bisphosphonates are currently approved for the treatment of Paget’s disease: The choice of the form of therapy, and thus in particular the drug therapy of Paget’s disease, must always be determined individually with regard to the substances administered, the dosage and the duration of the therapy. Combinations of the various … Bisphosphonates for therapy | Paget’s disease
