Effects The majority of antiparkinsonian drugs are directly or indirectly dopaminergic. Some are anticholinergic in action. Indications Parkinson’s disease, including drug-induced Parkinson’s disease in some cases. Drug treatment Overview of drug therapy: 1. dopaminergic agents Levodopa is a precursor of dopamine and is considered the most important and effective pharmacotherapy for PD. Combining it with … Antiparkinsonian
Products Pergolide (Permax) had been approved in tablet form in many countries since 1997. On Sept. 30, 2011, Permax went off the market in many countries. The reason given for the market withdrawal was a fire at the packaging plant. Other dopamine agonists are available as alternatives. Structure and properties Pergolide (C19H26N2S, Mr = 314.5 … Pergolide
Products Dopamine agonists are commercially available in the form of tablets, sustained-release tablets, transdermal patches, and injectables, among others. Structure and properties The first active ingredients, such as bromocriptine (Figure), were derived from ergot alkaloids. These are referred to as ergoline dopamine agonists. Later, agents with a nonergoline structure, such as pramipexole, were also developed. … Dopamine Agonists
Symptoms Symptoms depend on sex, age, adenoma size, and prolactin levels. In women, prolactinoma manifests as menstrual irregularities (absence or delay of periods), infertility, and lactation. In men, it results in testosterone deficiency, reduced libido, erectile dysfunction, impotence, decreased beard growth, and rarely breast pain and lactation. In children, puberty is additionally delayed. In a … Prolactinomas
Pergolide is an active ingredient isolated from naturally occurring fungal alkaloids and is approved as a therapeutic agent for Parkinson’s disease. It is also used in veterinary medicine for the treatment of an equine disease. Pergolide acts on the receptors of the neurotransmitter dopamine. What is pergolide? Pergolide drugs are used as a monopreparation for … Pergolide: Effects, Uses & Risks
Structure and properties Depending on the side chains, ergot alkaloids are classified into two different groups: Ergometrine-type ergot alkaloids (e.g., ergometrine, methylergometrine). Peptide-type ergot alkaloids (e.g., ergotamine, ergotoxine, bromocriptine). Effects Ergot alkaloids exhibit the following effects in varying degrees: Partial agonists at alpha-adrenoreceptors. Partial agonists at serotonin receptors Stimulation of dopamine receptors Contraction of vascular … Ergot Alkaloids
