Products Tafenoquine was approved in the United States in 2018 in tablet form (Krintafel, Arakoda). Structure and properties Tafenoquine (C24H28F3N3O3, Mr = 463.5 g/mol) is an 8-aminoquinoline derivative present in the drug as tafenoquine succinate. It is a derivative of primaquine. The drug was first synthesized in 1978 at the Walter Reed Army Institute of … Tafenoquine
Primaquine is a prescription drug with anti-parasitic properties. It is used for the prevention, treatment, and follow-up of malaria. In its guidelines for the treatment of malaria, the German Society for Tropical Medicine and International Health (DTG) recommends primaquine as an adjunctive therapy to chloroquine in the treatment of malaria tertiana. In Germany, primaquine is … Primaquine: Effects, Uses & Risks
Products No medicines containing primaquine are currently registered in many countries. Structure and properties Primaquine (C15H21N3O, Mr = 259.3 g/mol) is an 8-aminoquinoline derivative and a racetate. It is present in drugs as primaquine bishydrogen phosphate, an orange crystalline powder that is soluble in water. Primaquine is derived from plasmoquine. It was developed in the … Primaquine
Symptoms Malaria (Italian, “bad air”) manifests itself in the following symptoms, which usually appear a few weeks after transmission. The incubation period ranges from a few days to several years: High fever, sometimes with rhythmic attacks of fever, every second or third day. However, the fever may also occur irregularly. Chills, profuse sweating. Headache, muscle … Malaria Causes and Treatment
Effects Antiparasitic against plasmodia. Indications Malaria Malaria prophylaxis Also for the treatment of rheumatic diseases, lupus erythematosus. Off-label: some antimalarials such as quinine and chloroquine are used off-label to treat calf cramps. Active ingredients Aminoquinolines: Amodiaquine Chloroquine (Nivaquine, out of commerce). Hydroxychloroquine (Plaquenil) Mepacrine Pamaquin Piperaquine Primaquine Tafenoquin (crinoline) Biguanides: Proguanil (Malarone + Atovaquone). Cycloguanilembonate … Antimalarials
