Products Bazedoxifene is commercially available in the form of film-coated tablets (Conbriza). It has been approved in many countries since 2010. In 2015, a fixed combination with conjugated estrogens was registered (Duavive). This article refers to monotherapy. Structure and properties Bazedoxifene (C30H34N2O3, Mr = 470.60 g/mol) is a nonsteroidal selective estrogen receptor modulator developed from … Bazedoxifene
Products Doping agents include approved drugs, legal and illegal intoxicants, experimental agents, and illegally manufactured and trafficked substances. Doping includes non-drug doping methods, such as blood doping, in addition to drugs. Effects Doping agents differ in their pharmacological activities. Stimulants, for example, stimulate and thus increase alertness and aggressiveness for competition. In contrast, beta-blockers provide … Doping in Competitive Sports
Products Raloxifene is commercially available in the form of film-coated tablets (Evista). It has been approved in many countries since 2000. Structure and properties Raloxifene (C28H27NO4S, Mr = 473.6 g/mol) is present in the drug as raloxifene hydrochloride, a benzothiophene and white to yellowish powder that is sparingly soluble in water. Effects Raloxifene (ATC G03XC01) … Raloxifene
Symptoms A hot flash is a spontaneous feeling of warmth that may be accompanied by sweating, palpitations, flushing of the skin, feelings of anxiety, and subsequent chills, and lasts for a few minutes. The flushes affect mainly the head and upper body, but sometimes the whole body. The flushes often also occur at night, are … Floods
Symptoms In osteoporosis, bones become weak, porous, and brittle and undergo structural changes. Even minor stresses can lead to a fracture, especially of the vertebrae, femoral neck, and wrists. Fractures pose a risk to the elderly and can lead to pain, hospitalization, surgery and disability. In the worst cases, they are even life-threatening. Other possible … Osteoporosis Causes and Treatment
Osteoporosis is a dysbalance in the continuous build-up and breakdown of bone substance, which results in a reduction in bone density. The most at risk are older people who suffer a reduction in bone density simply due to aging processes, and among them especially women after the menopause, as the hormonal changes can have a … What pain does osteoporosis cause?
Pain in the spine Pain in the back and spine can generally occur in any patient suffering from osteoporosis. However, they are particularly typical in women after the menopause. For them, pain in the spine is often the first symptom of the disease. Nevertheless, it must of course be mentioned that osteoporosis is only one … Pain in the spine | What pain does osteoporosis cause?
Pain therapy For the long-term treatment of pain it is of course essential to treat the cause – in this case osteoporosis – in a targeted manner (see below). In the short term, common painkillers such as ibuprofen or diclofenac provide relief for mild to moderate pain. However, these should not be taken over a … Pain therapy | What pain does osteoporosis cause?
Duration of pain Due to the individual differences in severity and localization, it is not possible to make general statements about the duration of pain. Some patients, especially those in advanced stages of the disease, never become permanently pain-free, even under optimal treatment. Others respond very well to the therapy and achieve extensive or even … Duration of pain | What pain does osteoporosis cause?
