Products Pegloticase is commercially available as a concentrate for the preparation of an infusion solution (Krystexxa). The drug is not currently registered in many countries. Structure and properties Pegloticase is a recombinant uricase conjugated to mPEG (monomethoxypolyethylene glycol). It is obtained from genetically modified using biotechnological methods. The active ingredient has a molecular weight of … Pegloticase
Symptoms Gout is an inflammatory disease of the joints that manifests acutely in attacks of severe pain that worsens with pressure, touch, and movement. The joints are swollen with inflammation, and the skin is red and warm. Fever is observed. Gout often begins in the lower extremities and at the metatarsophalangeal joint (podagra). Urat crystals … Gout Causes and Treatment
Products Therapeutic proteins are usually administered in the form of injection and infusion preparations and must be stored in a refrigerator. The first recombinant protein to be approved was human insulin in 1982. Some proteins, for example, are also available in tablet, capsule, and powder form and can be stored at room temperature, such as … Therapeutic Proteins
Products Rasburicase is commercially available as an injectable (Fasturtec). It has been approved in many countries since 2002. Structure and properties Rasburicase is a recombinant urate oxidase enzyme produced by a genetically modified strain of yeast. Effects The enzyme rasburicase (ATC V03AF07) catalyzes the enzymatic oxidation of uric acid into allantoin, a water-soluble substance that, … Rasburicase
Products Enzymes are commercially available as drugs in the form of tablets, lozenges, capsules, as well as injection and infusion preparations, among others. Many products are subject to prescription, but there are also some agents which are released for the OTC market. Structure and properties Therapeutic enzymes are usually proteins, i.e. polymers of amino acids, … Therapeutic Enzymes
