Production Anise (crushed) 15 g Bitter Orange Blossom (5600) 20 g Peppermint leaves (5600) 10 g Melissa leaves (5600) 10 g Passionflower herb (5600) 20 g Valerian root (4000) 25 g The herbal drugs are mixed. Effects Calming tea is sedative, sleep-inducing and antispasmodic. Indications The tea mixture is used against, among others, nervousness, restlessness, … Drinking Tea to Calm Down
Products Sedatives are commercially available in the form of tablets, melting tablets, drops, as injectables and tinctures, among others. Structure and properties Sedatives do not have a uniform chemical structure. Effects The active ingredients have sedative properties. Some are additionally antianxiety, sleep-inducing, antipsychotic, antidepressant, and anticonvulsant. The effects are due to promotion of inhibitory mechanisms … Sedative
Products In many countries, drugs containing butalbital are no longer approved (e.g., Cafergot-PB). Combination products are still on the market in some countries, including the United States, where numerous products are available. Structure and properties Butalbital (C11H16N2O3, Mr = 224.3 g/mol) or 5-allyl-5-isobutylbarbituric acid exists as a slightly bitter, white, odorless, crystalline powder that is … Butalbital
Products Anxiolytics are commercially available in the form of tablets, capsules, and injectable preparations, among others. Structure and properties Anxiolytics are a structurally heterogeneous group. However, the representatives can be divided into different classes. These include, for example, the benzodiazepines or the tricyclic antidepressants. Effects Anxiolytics have antianxiety (anxiolytic) properties. They usually have additional effects, … Anxiolytics
Products Orexin receptor antagonists are commercially available in tablet form. The first agent in this group to be approved in the United States was suvorexant (Belsomra) in 2014. Lemborexant (Dayvigo) followed in 2019. Structure and properties Orexin receptor antagonists are characterized by a central ring structure to which heterocycles are attached on both sides. Effects … Orexin Receptor Antagonists
Products Methaqualone was launched in the 1960s and is now off the market in many countries. Toquilone compositum (fixed combination with diphenhydramine) was withdrawn from the market in late 2005. Methaqualone is now one of the more tightly controlled narcotics (schedule a). Structure and properties Methaqualone (C16H14N2O, Mr = 250.3 g/mol) is a quinazoline derivative. … Methaqualone
Products Eszopiclone is commercially available in the United States in the form of film-coated tablets (Lunesta). The drug is not registered in many countries. In contrast, the racemate zopiclone (Imovane) is on the market. Structure and properties Eszopiclone (C17H17ClN6O3, Mr = 388.8 g/mol) is the -enantiomer of zopiclone. It belongs to the cyclopyrrolones. Eszopiclone exists … Eszopiclone
Products Clomethiazole is commercially available in capsule form and as a mixture (Distraneurin, UK: Heminevrin). It was developed at Roche in the 1930s. Structure and properties Clomethiazole (C6H8ClNS, Mr = 161.65 g/mol) is a chlorinated and methylated thiazole derivative. The compound is related to the thiazole moiety of vitamin B1 (thiamine). Effects Clomethiazole (ATC N05CM02) … Clomethiazole
Products Trimipramine is commercially available in tablet and drop form (Surmontil, generic). It has been approved in many countries since 1962. Structure and properties Trimipramine (C20H26N2, Mr= 294.5 g/mol) is present in drugs as trimipramine mesilate or trimipramine maleate, a racemate and white crystalline powder that is sparingly soluble in water. It is structurally closely … Trimipramine
Products Tricyclic antidepressants are commercially available in many countries in the form of dragées, tablets, capsules, and drops. The first representative, imipramine, was developed at Geigy in Basel. Its antidepressant properties were discovered in the 1950s by Roland Kuhn at the psychiatric clinic in Münsterlingen (Thurgau). Imipramine was approved in many countries in 1958. Structure … Tricyclic Antidepressants
Products Lemborexant was approved in the United States in 2019 in film-coated tablet form (Dayvigo). This as the second agent in the orexin receptor antagonist group. Structure and properties Lemborexant (C22H20F2N4O2, Mr = 410.42 g/mol) is a pyrimidine and pyridine derivative. It exists as a white powder and is practically insoluble in water. Effects Lemborexant … Lemborexant
Products Most antidepressants are commercially available in the form of film-coated tablets. In addition, oral solutions (drops), meltable tablets, dispersible tablets, and injectables are also available, among others. The first representatives were developed in the 1950s. It was discovered that the antituberculosis drugs isoniazid and iproniazid (Marsilid, Roche) had antidepressant properties. Both agents are MAO … Antidepressants
