Introduction Tacrolimus is a drug which is used to inhibit and modulate the immune system. It is often used to inhibit transplant rejection, some autoimmune diseases and chronic inflammatory skin diseases. The active ingredient is derived from Gram-positive bacteria of the genus Streptomyces and shows structural similarity to the group of macrolide antibiotics. Tacrolimus was … Tacrolimus
Interactions with Tacrolimus Tacrolimus is almost completely metabolized in the liver by an enzyme (CYP34A) after absorption into the body. Since many other drugs are metabolized by the same enzyme, simultaneous intake may lead to interactions with the risk of an increased or decreased effect. If tacrolism is used after a transplant, there is a … Interactions with Tacrolimus | Tacrolimus
Dosage forms Tacrolimus can be used topically in form of an ointment or cream. It is often used for neurodermatitis (atopic eczema), an allergic hypersensitivity reaction (type I), in which the skin is reddened over a large area with severe itching in typical areas (especially in the area of the large bends). By applying an … Dosage forms | Tacrolimus
Mode of action of Tacrolimus Tacrolimus intervenes in the activation of the immune system after recognition of foreign structures (e.g.B. Fragments of bacteria/viruses, transplants, etc.) These structures are presented to T cells of the immune system by antigen presenting cells. Subsequently, the synthesis of important messenger substances (interleukins, among others) takes place within the T … Mode of action of Tacrolimus | Tacrolimus
